3-Methylcrotonyl Glycine

3-Methylcrotonyl glycine (3-MCG) is a metabolite found in the urine of patients with 3-methylcrotonyl glycinuria, a metabolic disorder characterized by a deficiency in 3-methylcrotonyl-CoA carboxylase, that has diverse biological activities. It inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner. It also inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum, indicating a potential role for this metabolite in the development of CNS damage associated with 3-methycrotonyl glycinuria.Formal Name: N-(3-methyl-1-oxo-2-buten-1-yl)-glycine. CAS Number: 33008-07-0. Synonyms: 3-MCG, beta-Methylcrotonyl Glycine. Molecular Formula: C7H11NO3. Formula Weight: 157.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 20 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 217 nm. SMILES: OC(CNC(/C=C(C)/C)=O)=O. InChi Code: InChI=1S/C7H11NO3/c1-5(2)3-6(9)8-4-7(10)11/h3H,4H2,1-2H3,(H,8,9)(H,10,11). InChi Key: PFWQSHXPNKRLIV-UHFFFAOYSA-N.