3,3'-Diiodo-L-thyronine

3,3'-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3'-T2. It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an active metabolite of the thyroid hormones 3,3',5-triiodo-L-thryonine (T3, Cay-30996) and 3,3',5'-triiodo-L-thryonine (reverse T3, Cay-17598). It is formed from T3 or reverse T3 via deiodination by peripheral deiodinases. 3,3'-T2 increases cytochrome c oxidase activity in osmotically treated mitochondria from the livers of hypothyroid and euthyroid rats and increases cytochrome c oxidase activity in liver homogenates from hypothyroid rats at 1 µM. It increases the resting metabolic rate by 27% and cytochrome c oxidase activity in the heart, liver, muscles, and brown adipose tissue (BAT) in a rat model of hypothyroidism. 3,3'-T2 (250 µg/kg, i.p.) increases autophagy and reduces hepatic lipid accumulation in rats fed a high-fat diet.. SMILES: OC([C@@H](N)CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C=C1)=O. InChi Code: InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1. InChi Key: CPCJBZABTUOGNM-LBPRGKRZSA-N