23-hydroxy Betulinic Acid

23-hydroxy Betulinic acid is a triterpenoid that has been found in P. chinensis and has anticancer activity. It inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 µM, respectively), as well as human umbilical vein endothelial cells (HUVECs, IC50 = 94.8 µM). It halts the cell cycle at the S phase and induces apoptosis in K562 cells in a concentration-dependent manner with a loss of the mitochondrial membrane potential and an increase in Bax and cytochrome C protein levels.Formal Name: (3beta,4alpha)-3,23-dihydroxy-lup-20(29)-en-28-oic acid. CAS Number: 85999-40-2. Synonyms: 23-HBA. Molecular Formula: C30H48O4. Formula Weight: 472.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 1 mg/ml. SMILES: CC([C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])[C@@](CO)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H])=C. InChi Code: InChI=1S/C30H48O4/c1-18(2)19-9-14-30(25(33)34)16-15-28(5)20(24(19)30)7-8-22-26(3)12-11-23(32)27(4,17-31)21(26)10-13-29(22,28)6/h19-24,31-32H,1,7-17H2,2-6H3,(H,33,34)/t19-,20+,21+,22+,23-,24+,26-,27-,28+,29+,30-/m0/s1. InChi Key: HXWLKAXCQLXHML-WGOZWDAUSA-N. Origin: Plant/Anemone chinensis.