2-Thiouridine

2-Thiouridine (s2U) is a modified nucleobase found in tRNAs that is known to stabilize U:A pairs and modestly destabilize U:G wobble pairs. Modified nucleobases, including 2-thiouridine, are used to study nucleic acid structure and function as well as to engineer novel RNA-based biomolecules.Formal Name: 2-thio-uridine. CAS Number: 20235-78-3. Synonyms: 1-beta-D-ribofuranosyl-2-thiouracil, s2U. Molecular Formula: C9H12N2O5S. Formula Weight: 260.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 219, 273 nm. SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC(NC2=S)=O)O1. InChi Code: InChI=1S/C9H12N2O5S/c12-3-4-6(14)7(15)8(16-4)11-2-1-5(13)10-9(11)17/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,17)/t4-,6-,7-,8-/m1/s1. InChi Key: GJTBSTBJLVYKAU-XVFCMESISA-N.