2'-O-Methylguanosine

2'-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase, using S-adenosyl-L-methionine (Cay-16376, Cay-13956) as a substrate. Through its interaction with other modified nucleosides, 2'-O-methylguanosine is thought to stabilize the structure of the tRNA. 2'-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2'-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.Formal Name: 2'-O-methyl-guanosine. CAS Number: 2140-71-8. Molecular Formula: C11H15N5O5. Formula Weight: 297.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M HCl: 10 mg/ml, DMF: 50 µg/ml, DMSO: 12 mg/ml, Ethanol: 50 µg/ml. lambdamax: 253 nm. SMILES: O=C1C2=C(N([C@H]3[C@H](OC)[C@H](O)[C@@H](CO)O3)C=N2)N=C(N)N1. InChi Code: InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1. InChi Key: OVYNGSFVYRPRCG-KQYNXXCUSA-N.