2-Hydroxypropyl-beta-cyclodextrin

2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-beta-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility. HP-beta-CD is a mixture containing HP-beta-CD with variable hydroxypropyl group substitutions.Formal Name: 2-hydroxypropyl ethers beta-cyclodextrin. CAS Number: 128446-35-5. Synonyms: HP-beta-CD. Molecular Formula: (C6H9O5)7(C3H7O). Formula Weight: 1541.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 50 mg/ml. SMILES: O[C@H]1[C@@](O[C@](O[C@H](COCC(O)C)[C@](O[C@](O[C@H](COCC(C)O)[C@](O[C@](O[C@H](COCC(O)C)[C@](O2)([H])[C@@H]3O)([H])[C@@H]3O)([H])[C@@H]4O)([H])[C@@H]4O)([H])[C@@H]5O)([H])[C@@H]5O)([H])[C@H](O[C@@](O[C@]([C@@H]6O)([H])[C@H](O[C@@](O[C@]([C@@H]7O)([H])[C@H](O[C@@](O[C@]([C@@H]8O)([H])[C@H](O[C@@]2([H])[C@@H]8O)COCC(O)C)([H])[C@@H]7O)COCC(O)C)([H])[C@@H]6O)COCC(C)O)([H])[C@@H]1O)COCC(O)C. InChi Code: InChI=1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-/m1/s1. InChi Key: ODLHGICHYURWBS-LKONHMLTSA-N.