2-Guanidinoethylmercaptosuccinic Acid

Enkephalin convertase, also known as carboxypeptidase E, removes C-terminal residues during the processing of propeptides, including enkephalin and proinsulin. 2-Guanidinoethylmercaptosuccinic acid (GEMSA) is a potent inhibitor of enkephalin convertase (Ki = 8.8 nM) that is functional in vivo. It is a peptidomimetic inhibitor, occupying the specificity pocket of the enzyme. GEMSA can also inhibit other carboxypeptidases, including thrombin-activatable fibrinolysis inhibitor.Formal Name: 2-[[2-[(aminoiminomethyl)amino]ethyl]thio]-butanedioic acid. CAS Number: 77482-44-1. Synonyms: GEMSA. Molecular Formula: C7H13N3O4S. Formula Weight: 235.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: OC(C(CC(O)=O)SCCNC(N)=N)=O. InChi Code: InChI=1S/C7H13N3O4S/c8-7(9)10-1-2-15-4(6(13)14)3-5(11)12/h4H,1-3H2,(H,11,12)(H,13,14)(H4,8,9,10). InChi Key: VKVCLXDFOQQABP-UHFFFAOYSA-N.