2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)

Description: 2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome. Target: Others. Smiles: O.[Na+].[Na+].Nc1nc2n(cnc2c(=O)[nH]1)C1CC(O)C(COP([O-])([O-])=O)O1