2'-C-beta-Methylguanosine

2'-C-beta-Methylguanosine is an active nucleoside metabolite of the antiviral prodrug BMS-986094. It inhibits replication in genotype 1b hepatitis C virus (HCV) replicon cells (EC50s = 5.2 and 3.2 µM in ELISA and luciferase assays, respectively). 2'-C-beta-Methylguanosine also inhibits replication of the Zika virus clinical isolate ZIKVPE243 in infected human brain microvascular endothelial cells (HBMECs), SH-SY5Y cells, and Vero cells (EC50s = 0.88, 2.09, and 1.25 µM, respectively) but is toxic to mice infected with ZIKVPE243 at postnatal day 2 when administered at a dose of 25 mg/kg per day.Formal Name: 2'-C-methyl-guanosine. CAS Number: 374750-30-8. Molecular Formula: C11H15N5O5. Formula Weight: 297.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 255 nm. SMILES: C[C@@]1([C@](O[C@@H]([C@H]1O)CO)([H])N2C3=C(C(N=C(N3)N)=O)N=C2)O. InChi Code: InChI=1S/C11H15N5O5/c1-11(20)6(18)4(2-17)21-9(11)16-3-13-5-7(16)14-10(12)15-8(5)19/h3-4,6,9,17-18,20H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,9-,11-/m1/s1. InChi Key: NVKAMPJSWMHVDK-GITKWUPZSA-N.