17-AAG

17-AAG is an inhibitor of heat shock protein 90 (Hsp90) and a derivative of geldanamycin (Cay-13355) that selectively inhibits BT474 tumor cell Hsp90 over fibroblast Hsp90 (IC50s = 5 and 943 nM, respectively). It inhibits the growth of prostate cancer cell lines (IC50s = 25-45 nM) and promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50s = 4-72 nM). In vivo, 17-AAG (25 mg/kg, i.p.) reduces tumor size in a G-415 gallbladder cancer mouse xenograft model.Formal Name: 17-demethoxy-17-(2-propenylamino)-geldanamycin. CAS Number: 75747-14-7. Synonyms: BMS 722782, CP 127374, KOS 953, NSC 330507, Tanespimycin. Molecular Formula: C31H43N3O8. Formula Weight: 585.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 219, 239, 332, 528 nm. SMILES: C=CCNC(C(C=C1NC2=O)=O)=C(C[C@H](C[C@@H]([C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C([H])=C(\C=C2/C)[H])OC)C)C1=O. InChi Code: InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25. InChi Key: AYUNIORJHRXIBJ-TXHRRWQRSA-N.