16F16

16F16 is a protein disulfide isomerase (PDI) inhibitor. It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 µg/ml. 16F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 µM) reduces HTTN90Q73 mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-beta precursor protein (APP) in rat corticostriatal slices.Formal Name: 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid, methyl ester. CAS Number: 922507-80-0. Molecular Formula: C16H17ClN2O3. Formula Weight: 320.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mg/ml. SMILES: O=C(CCl)N1C(C(OC)=O)(C)C2=C(C(C=CC=C3)=C3N2)CC1. InChi Code: InChI=1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3. InChi Key: BCSIRYFYAKLJDK-UHFFFAOYSA-N.