15(S)-Latanoprost

Description: 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 µg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys. 15(S)-Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product. Target: Others. Smiles: C(/C=C\CCCC(OC(C)C)=O)[C@@H]1[C@@H](CC[C@@H](CCC2=CC=CC=C2)O)[C@H](O)C[C@@H]1O