13-Methylberberine (chloride)

13-Methylberberine (13-MB) (chloride) is a 13-methyl-substituted derivative of berberine (Cay-10006427). Berberine is a widely distributed berberidaceaen alkaloid found in plant tissues that has antibacterial, anti-inflammatory, antitumor, anti-obesity, and hypercholesterolemic activity. 13-MB has improved antibacterial activity against S. aureus (MIC = 125 µg/ml) and improved antitumor activity with a mean GI50 value of 11.7 µM, as compared to berberine. 13-MB also induces down-regulation of adipocyte differentiation transcription factors, reduces de novo lipid synthesis, and accumulates in murine 3T3-L1 adipocytes at higher levels than berberine, suggesting improved anti-obesity activity.Formal Name: 5,6-dihydro-9,10-dimethoxy-13-methyl-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride. CAS Number: 54260-72-9. Synonyms: 13-MB. Molecular Formula: C21H20NO4 . Cl. Formula Weight: 385.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 1 mg/ml. lambdamax: 232, 266, 342, 423 nm. SMILES: COC1=CC=C2C(C)=C3[N+](CCC4=C3C=C5C(OCO5)=C4)=CC2=C1OC.[Cl-]. InChi Code: InChI=1S/C21H20NO4.ClH/c1-12-14-4-5-17(23-2)21(24-3)16(14)10-22-7-6-13-8-18-19(26-11-25-18)9-15(13)20(12)22,/h4-5,8-10H,6-7,11H2,1-3H3,1H/q+1,/p-1. InChi Key: MLEFNGNLISNJEQ-UHFFFAOYSA-M.