10-Gingerol

10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH (Cay-14805), superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 µM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP, Cay-21495) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 µM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against M. avium and M. tuberculosis (MICs = 25 and 50 µg/ml, respectively). 10-Gingerol (200 µM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.Formal Name: 5S-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone. CAS Number: 23513-15-7. Molecular Formula: C21H34O4. Formula Weight: 350.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 281 nm. SMILES: OC1=CC=C(CCC(C[C@@H](O)CCCCCCCCC)=O)C=C1OC. InChi Code: InChI=1S/C21H34O4/c1-3-4-5-6-7-8-9-10-18(22)16-19(23)13-11-17-12-14-20(24)21(15-17)25-2/h12,14-15,18,22,24H,3-11,13,16H2,1-2H3/t18-/m0/s1. InChi Key: AIULWNKTYPZYAN-SFHVURJKSA-N. Origin: Plant/Zingiber officinale.