1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

Description: 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1] It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3]. Target: Others. Smiles: [Na].[H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)NCCOP(O)(=O)OC[C@@H](COC(=O)CCCCCCCCCC CCCCC)OC(=O)CCCCCCCCCCCCCCC)[C@@]1([H])NC(=O)N2. References: Yeh, P.-Y., Chen, Y.-R., Wang, C.-F., et al. Promoting multivalent antibody-antigen interactions by tethering antibody molecules on a PEGylated dendrimer-supported lipid bilayer. Biomolecules 19(2), 426-437 (2018).