Tyrothricin

Tyrothricin is a polypeptide antibiotic mixture produced by B. brevis. Tyrothricin is a mixture of tyrocidine and gramicidin that has rapid in vitro bactericidal activity against T. microdentium, T. macrodentium, T. vincentii, T. buccalis, T. mucosum, T. vaginalis, T. cruzi, and L. tropica. Preclinical studies demonstrate that intravenous use of tyrothricin leads to hemolysis-induced lethality (LD50s = 0.4 and 0.3 mg/kg, in dogs and mice, respectively) and damages liver, kidney, and olfactory tissues. Formulations containing tyrothricin are used topically to treat bacterial skin infections.CAS Number: 1404-88-2. Molecular Formula: C66H87N13O13 (for Tyrocidine A). Purity: >95% composite purity (based on 80% tyrocidine and 20% gramicidin complexes). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(N1CCC[C@]1(C(N[C@@H](CC2=CC=CC=C2)C(N[C@]([H])(CC3=CC=CC=C3)C(N[C@@H](CC(N)=O)C(N[C@H]4CCC(N)=O)=O)=O)=O)=O)[H])[C@@]([H])(CC5=CC=CC=C5)NC([C@H](CC(C)C)NC([C@]([H])(CCCN)NC([C@H](C(C)C)NC([C@H](CC6=CC=C(C=C6)O)NC4=O)=O)=O)=O)=O.O=C(N[C@@H](C)C(N[C@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C(N[C@H](C(N[C@H](C(C)C)C(N[C@H](C(N[C@H](CC(C)C)C(N[C@H](C(N[C@H](CC(C)C)C(N[C@@H](CC7=CNC8=C7C=CC=C8)C(N[C@H](CC(C)C)C(N[C@@H](CC9=CNC%10=C9C=CC=C%10)C(NCCO)=O)=O)=O)=O)=O)CC%11=CNC%12=C%11C=CC=C%12)=O)=O)CC%13=CNC%14=C%13C=CC=C%14)=O)=O)C(C)C)=O)C(C)C)=O)=O)=O)CNC([C@H](C(C)C)NC([H])=O)=O. InChi Code: InChI=1S/C99H140N20O17.C66H87N13O13/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69,1-38(2)32-47-59(85)77-52(36-42-20-12-7-13-21-42)66(92)79-31-15-23-53(79)64(90)76-49(34-41-18-10-6-11-19-41)61(87)74-48(33-40-16-8-5-9-17-40)60(86)75-51(37-55(69)82)62(88)70-46(28-29-54(68)81)58(84)73-50(35-43-24-26-44(80)27-25-43)63(89)78-56(39(3)4)65(91)71-45(22-14-30-67)57(83)72-47/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135),5-13,16-21,24-27,38-39,45-53,56,80H,14-15,22-23,28-37,67H2,1-4H3,(H2,68,81)(H2,69,82)(H,70,88)(H,71,91)(H,72,83)(H,73,84)(H,74,87)(H,75,86)(H,76,90)(H,77,85)(H,78,89)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83+,84+,85-,45-,46-,47-,48+,49-,50-,51-,52+,53-,56-/m00/s1. InChi Key: ATKYBFJRKHIKCW-LATDSDEZSA-N.