Tinidazole

Tinidazole is a 5-nitroimidazole derivative with antiparasitic and antibiotic activity that exhibits a mean minimum inhibitory concentration of 0.31, 2.33, and 0.5 µg/mL against C. difficile, P. bivia, and B. fragilis, respectively. It is orally bioavailable and is rapidly metabolized to cytotoxic intermediates that covalently bind DNA, causing irreversible damage to susceptible cells. It shows efficacy against pathogenic protozoa (T. vaginalis, E. bistolytica, and G. duodenalis), clinically significant anaerobic bacteria (B. fragilis, C. difficile), and microaerophilic bacterium (H. pylori).Formal Name: 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole. CAS Number: 19387-91-8. Synonyms: CP 12,574. Molecular Formula: C8H13N3O4S. Formula Weight: 247.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 230, 310 nm. SMILES: CC1=NC=C([N+]([O-])=O)N1CCS(CC)(=O)=O. InChi Code: InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3. InChi Key: HJLSLZFTEKNLFI-UHFFFAOYSA-N.