Solithromycin

Solithromycin is a macrolide antibiotic with activity against Gram-positive and Gram-negative bacteria, including C. trachomatis and C. pneumoniae (MICs = 0.125-0.5 and 0.25-1 µg/ml, respectively). It also inhibits growth of multidrug resistant P. falciparum in vitro (IC50s = 0.5 nM for both Dd2 and 7G8 strains). Solithromycin (100 mg/kg) administered in a four-dose series eradicates P. berghei infection in mice.Formal Name: (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone. CAS Number: 760981-83-7. Molecular Formula: C43H65FN6O10. Formula Weight: 845.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2.5 mg/ml. lambdamax: 233, 311 nm. SMILES: O=C(N1CCCCN2N=NC(C3=CC=CC(N)=C3)=C2)O[C@]([C@@]1([H])[C@H]4C)(C)[C@@H](CC)OC([C@@](C)(F)C([C@H](C)[C@@H](O[C@@]5([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@](C)(OC)C[C@@H](C)C4=O)=O)=O. InChi Code: InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-. InChi Key: IXXFZUPTQVDPPK-ZAWHAJPISA-N.