Sandramycin

Sandramycin is a cyclic depsipeptide antibiotic that was first isolated from the culture broth of Nocardioides sp. It is active against Gram-positive bacteria in vitro and leukemia P388 tumors in mice. Sandramycin acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules.Formal Name: N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-L-valine, bimol. (5->1'3),(5'->13)-dilactone. CAS Number: 100940-65-6. Synonyms: (-)-Sandramycin. Molecular Formula: C60H76N12O16. Formula Weight: 1221.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C([C@@H](COC([C@@H](N(C(CN(C(CNC([C@@](CCCC1)([H])N1C2=O)=O)=O)C)=O)C)C(C)C)=O)NC(C3=NC(C=CC=C4)=C4C=C3O)=O)N(CCCC5)[C@]5([H])C(NCC(N(CC(N([C@H](C(OC[C@H]2NC(C6=NC(C=CC=C7)=C7C=C6O)=O)=O)C(C)C)C)=O)C)=O)=O. InChi Code: InChI=1S/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-. InChi Key: WXIVYIYCEBUEHL-RTQGILJWSA-N. Origin: Bacterium/Kribbella sp..