Resistoflavine (Antibiotic A 3733Y, Resistoflavin)

Resistoflavine is a rare, boat-shaped, pentacyclic polyketide isolated from several species of Streptomyces, often co-produced with resistomycin. Resistoflavine exhibits weak antibiacterial activity against Gram postive and Gram negative bacteria and exhibits potent cytotoxic activity against tumor cell lines in vitro. Resistoflavine inhibits growth, nucleic acid and protein synthesis in Bacillus subtilis. Source: Streptomyces sp. MST-AS5822 , Apperance: Brown solid, , Solubility: Soluble in DMF or DMSO with only limited solubility in ethanol and methanol. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.