Pyrazinamide

Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain (MIC = 150 µg/ml). It increases survival in M. tuberculosis H37Rv-infected mice when administered orally (0.1% w/w in the diet) or subcutaneously (2.5 mg single injection) on the day of infection. Pyrazinamide also inhibits the growth of M. lepraemurium in infected mice. Formulations containing pyrazinamide have been used as first-line treatments of M. tuberculosis.Formal Name: 2-pyrazinecarboxamide. CAS Number: 98-96-4. Synonyms: Aldinamide, alpha-Pyrazinamide, MK 56, Pyrazinecarboxamide, Pyrazinoic Acid Amide, NSC 14911. Molecular Formula: C5H5N3O. Formula Weight: 123.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 269 nm. SMILES: NC(C1=CN=CC=N1)=O. InChi Code: InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9). InChi Key: IPEHBUMCGVEMRF-UHFFFAOYSA-N.