Parvodicin C2

Parvodicin C2 is a glycopeptide antibiotic originally isolated from A. parvosata and a component of parvodicin complex (Cay-24036). It is also a component of the A40926 antibiotic complex, which has been used as a precursor in the synthesis of the antibiotic dalbavancin (Cay-21161). Parvodicin C2 is active against methicillin-sensitive strains of S. aureus, S. epidermidis, and S. saprophyticus (MICs = 0.4-12.5 µg/ml), as well as methicillin-resistant strains of S. aureus, S. hemolyticus, and E. faecalis (MICs = 0.2-50 µg/ml).Formal Name: 5,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(1-oxododecyl)amino]-beta-D-glucopyranuronosyl]-42-O-alpha-D-mannopyranosyl-N15-methyl-ristomycin A aglycone. CAS Number: 110882-85-4. Synonyms: Antibiotic A40926 B1. Molecular Formula: C83H88Cl2N8O29. Formula Weight: 1732.5. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: OC([C@H](C1=CC(O)=CC(O[C@@H](O[C@H](CO)[C@H]2O)[C@@H](O)[C@H]2O)=C1C3=CC([C@]4(NC([C@@]([H])5NC([C@]([H])(C6=C(Cl)C(O)=CC7=C6)NC([C@@](CC(C=C8)=CC=C8O9)(NC([C@H](NC)C%10=CC(O7)=C(O)C=C%10)=O)[H])=O)=O)=O)[H])=CC=C3O)NC([C@]([H])([C@H](O)C%11=CC=C(C(Cl)=C%11)OC%12=C(O[C@@H]([C@H](NC(CCCCCCCCCCC)=O)[C@@H](O)[C@@H]%13O)O[C@@H]%13C(O)=O)C9=CC5=C%12)NC4=O)=O)=O. InChi Code: InChI=1S/C83H88Cl2N8O29/c1-3-4-5-6-7-8-9-10-11-12-56(99)88-65-68(102)70(104)73(81(114)115)122-82(65)121-72-53-27-38-28-54(72)118-50-22-17-37(25-45(50)84)66(100)64-79(111)92-63(80(112)113)43-29-39(95)30-52(119-83-71(105)69(103)67(101)55(33-94)120-83)57(43)42-24-35(15-20-47(42)96)60(76(108)93-64)89-77(109)61(38)90-78(110)62-44-31-41(32-49(98)58(44)85)117-51-26-36(16-21-48(51)97)59(86-2)75(107)87-46(74(106)91-62)23-34-13-18-40(116-53)19-14-34/h13-22,24-32,46,55,59-71,73,82-83,86,94-98,100-105H,3-12,23,33H2,1-2H3,(H,87,107)(H,88,99)(H,89,109)(H,90,110)(H,91,106)(H,92,111)(H,93,108)(H,112,113)(H,114,115)/t46-,55-,59-,60-,61-,62+,63+,64+,65-,66-,67-,68-,69+,70+,71+,73+,82-,83+/m1/s1. InChi Key: IMGYVEMZPBHISV-PSDJNXLUSA-N. Origin: Synthetic.