Neoantimycin

Neoantimycin is an antibiotic originally isolated from S. orinoci that has slight antifungal activity. It is structurally similar to antimycin (Cay-19433) despite being produced by an unrelated species of Streptomyces. The biosynthetic pathway of neoantimycin has been determined and active analogs discovered.Formal Name: 3-(formylamino)-2-hydroxy-N-[(3S,6S,7R,10S,14R,15R)-14-hydroxy-7,13,13-trimethyl-3-(1-methylethyl)-10-[(1S)-1-methylpropyl]-2,5,9,12-tetraoxo-15-(phenylmethyl)-1,4,8,11-tetraoxacyclopentadec-6-yl]-benzamide. CAS Number: 22862-63-1. Molecular Formula: C36H46N2O12. Formula Weight: 698.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C([C@@](C(C)C)([H])OC([C@@H](NC(C1=C(O)C(NC=O)=CC=C1)=O)[C@@H](C)O2)=O)O[C@H](CC3=CC=CC=C3)[C@H](O)C(C)(C)C(O[C@]([C@@H](C)CC)([H])C2=O)=O. InChi Code: InChI=1S/C36H46N2O12/c1-8-20(4)29-34(45)47-21(5)26(38-31(42)23-15-12-16-24(27(23)40)37-18-39)32(43)49-28(19(2)3)33(44)48-25(17-22-13-10-9-11-14-22)30(41)36(6,7)35(46)50-29/h9-16,18-21,25-26,28-30,40-41H,8,17H2,1-7H3,(H,37,39)(H,38,42)/t20-,21+,25+,26-,28-,29-,30-/m0/s1. InChi Key: JIJATTFJYJZEBT-AXDSYHGFSA-N. Origin: Bacterium/Streptomyces sp..