NAI-857

Isolated from Strepomyces sp. Beige powder. Soluble in DMSO or water. Antibacterial class I lantibiotic. Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis. Interfers with late stages of cell wall biosynthesis leading to accumulation of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapeptide) in the cytoplasm less efficient than NAI-107. Active against Streptococcus pyogenes and weak antibacterial activity against other tested Gram-positive pathogens.