Moxifloxacin (hydrochloride)

Moxifloxacin is a fluoroquinolone antibiotic. It is active against 390 clinical isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria (MIC90s = =0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively). Moxifloxacin is an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays). It prevents S. aureus- or P. aeruginosa-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration and reduces S. aureus- or P. aeruginosa-induced increases in lung chemokine (C-X-C motif) ligand 1 (CXCL1) and IL-1beta levels in mouse models of bacterial pneumonia when administered at a dose of 100 mg/kg twice per day for two days. Moxifloxacin (100 mg/kg) decreases the number of lung and spleen colony forming units (CFUs) in a mouse model of systemic M. tuberculosis infection. Formulations containing moxifloxacin have been used in the treatment of various bacterial infections.Formal Name: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid, monohydrochloride. CAS Number: 186826-86-8. Synonyms: BAY 12-8039. Molecular Formula: C21H24FN3O4 . HCl. Formula Weight: 437.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3.33 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 215, 295, 329 nm. SMILES: O=C1C(C(O)=O)=CN(C2CC2)C3=C1C=C(F)C(N4C[C@](N([H])CCC5)([H])[C@]5([H])C4)=C3OC.Cl. InChi Code: InChI=1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24,/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28),1H/t11-,16+,/m0./s1. InChi Key: IDIIJJHBXUESQI-DFIJPDEKSA-N.