Minosaminomycin

Minosaminomycin is an antibiotic that has been found in Streptomyces. It is active against M. smegmatis and M. phlei (MICs = 1.56 and 6.25 µg/ml, respectively). Minosaminomycin (1 µM) inhibits the binding of formyl-Met-tRNA (fMet-tRNA) to ribosomes in the presence of the AUG trinucleotide by 96% in a cell-free assay and inhibits Mycobacterium protein synthesis when used at a concentration of 100 µM.Formal Name: 1-[[(2S)-3-[(4R)-2-amino-4,5-dihydro-1H-imidazol-4-yl]-2-[[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]amino]-1-oxopropyl]amino]-1-deoxy-4-O-(2,4-diamino-2,3,4,6-tetradeoxy-alpha-D-arabino-hexopyranosyl)-D-myo-inositol. CAS Number: 51746-09-9. Synonyms: MSM. Molecular Formula: C25H46N8O10. Formula Weight: 618.7. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble, Water: soluble. SMILES: O=C(C(CC(C)C)NC(NC(CC1CN=C(N)N1)C(NC2C(C(C(C(C2O)O)OC3OC(C(CC3N)N)C)O)O)=O)=O)O. InChi Code: InChI=1S/C25H46N8O10/c1-8(2)4-14(22(39)40)32-25(41)31-13(5-10-7-29-24(28)30-10)21(38)33-15-16(34)18(36)20(19(37)17(15)35)43-23-12(27)6-11(26)9(3)42-23/h8-20,23,34-37H,4-7,26-27H2,1-3H3,(H,33,38)(H,39,40)(H3,28,29,30)(H2,31,32,41). InChi Key: UDZJEGDQBWDMOF-UHFFFAOYSA-N. Origin: Bacterium/Streptomyces sp. MA514-A1.