Lolamicin

A Gram-negative-selective antibiotic, selective for Gram-negative pathogenic bacteria, such as E. coli, S. typhimurium, and E. cloacae (MICs = 0.008-8 µg/ml), over Gram-negative commensal bacteria and Gram-positive pathogenic and commensal bacteria (MICs = >128 µg/ml), active against multidrug-resistant clinical isolates of E. coli, K. pneumoniae, and E. cloacae, increases survival and decreases lung CFUs in multiple mouse models of septicemia and pneumonia, respectively, at 100 mg/kg, does not affect fecal bacterial taxonomic composition in healthy mice nor allow C. difficile colonization in C. difficile-challenged mice at 200 mg/kg