Lagosin

Lagosin is a polyene macrolide that has been found in Streptomyces and has antimicrobial activity. It is active against C. albicans, as well as the plant pathogenic fungus R. solani (MICs = 10 and 72 µg/ml, respectively). Lagosin is also active against several strains of T. vaginalis that are sensitive or resistant to the antibiotic metronidazole (Cay-9002409, EC50s = 1.74-2.62 µg/ml after a one-hour incubation).Formal Name: (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one. CAS Number: 6834-98-6. Synonyms: Cogomycin, 14-hydroxy Filipin, Fungichromin, NSC 105388, NSC 276732, Pentamycin. Molecular Formula: C35H58O12. Formula Weight: 670.8. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: C/C1=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@@H]1O)=O. InChi Code: InChI=1S/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14+/t23-,24+,25-,26+,. InChi Key: AGJUUQSLGVCRQA-SWOUQTJZSA-N. Origin: Bacterium/Streptomyces sp..