Gentamicin sulfate

Gentamicin sulfate is a broad-spectrum aminoglycoside antibiotic used to treat a wide range of bacterial infections. It is antibacterial against Gram-negative aerobic bacteria, Gram-positive bacteria and mycoplasmas. Gentamicin sulfate is a protein synthesis inhibitor. It causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. Gentamicin sulfate is used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It is a broad-spectrum cell culture antibiotic that is nontoxic to viruses and mammalian cells at antibacterial and antimycoplasmal concentrations. Due to its extended stability and slow development of bacterial resistance, it is a useful antibiotic in long-term virus und tissue culture studies.