Fosfomycin Trometamol

Fosfomycin trometamol is a broad-spectrum antibiotic that is active against Gram-negative and Gram-positive bacteria with MIC90 values of 8, 32, 4, and 32 µg/mL for ESBL E. coli, carbapenemase-producing K. pneumoniae, P. mirabilis, and methicillin-resistant S. saprophyticus, respectively, in a broth microdilution assay. It is an inhibitor of uridine diphospho-N-acetyl-D-glucosamine enolpyruvyl transferase (MurA) that enters cells via the glycerol-3-phosphate and hexose-6-phosphate transporters. Formulations containing fosfomycin trometamol have been used in the treatment of urinary tract infections.Formal Name: P-[(2R,3S)-3-methyl-2-oxiranyl]-phosphonic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol. CAS Number: 78964-85-9. Synonyms: Fosfomycin Tromethamine. Molecular Formula: C4H11NO3 . C3H7O4P. Formula Weight: 259.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: Slightly soluble, Water: Soluble. SMILES: C[C@H]1[C@@H](P(O)(O)=O)O1.OCC(CO)(N)CO. InChi Code: InChI=1S/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8,1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2,2-3H,1H3,(H2,4,5,6)/t,2-,3+/m.0/s1. InChi Key: QZJIMDIBFFHQDW-LMLSDSMGSA-N.