Enramycin B

Enramycin B is a lipopeptide antibiotic that has been found in S. fungicidicus. It also inhibits avian myeloblastosis virus reverse transcriptase by 70% when used at a concentration of 40 µg/ml in a cell-free assay. Formulations containing enramycin B have been used as feed additives to prevent bacterial necrotic enteritis in livestock.Formal Name: (2S)-N-[(2Z,4E)-10-methyl-1-oxo-2,4-dodecadien-1-yl]-L-alpha-aspartyl-L-threonyl-(2R)-2-(4-hydroxyphenyl)glycyl-D-ornithyl-D-allothreonyl-(2S)-2-(4-hydroxyphenyl)glycyl-(2R)-2-(4-hydroxyphenyl)glycyl-L-allothreonyl-N5-(aminocarbonyl)-L-ornithyl-3-[(5R)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-D-alanyl-(2S)-2-(4-hydroxyphenyl)glycyl-D-seryl-(2S)-2-(3,5-dichloro-4-hydroxyphenyl)glycylglycyl-3-[(5R)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-L-alanyl-D-alanyl-2-(4-hydroxyphenyl)-glycine, (17->2)-lactone. CAS Number: 34304-21-7. Synonyms: Enduracidin B. Molecular Formula: C108H140Cl2N26O31. Formula Weight: 2369.4. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly soluble: 0.1-1 mg/ml, Water: Slightly soluble: 0.1-1 mg/ml. SMILES: O=C(/C=C\C=C\CCCCC(C)CC)N[C@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@@](C(N[C@H]1C2=CC=C(O)C=C2)=O)([C@H](O)C)[H])=O)CCCN)=O)C3=CC=C(O)C=C3)=O)[C@@H](C)OC([C@@H](NC([C@@H](C)NC([C@H](C[C@@]4([H])NC(N)=NC4)NC(CNC([C@@H](NC([C@@H](CO)NC([C@@H](NC([C@@H](C[C@H]5NC(N)=NC5)NC([C@H](CCCNC(N)=O)NC([C@@](NC([C@H](NC1=O)C6=CC=C(O)C=C6)=O)([C@H](C)O)[H])=O)=O)=O)C7=CC=C(O)C=C7)=O)=O)C8=CC(Cl)=C(O)C(Cl)=C8)=O)=O)=O)=O)C9=CC=C(O)C=C9)=O)=O)CC(O)=O. InChi Code: InChI=1S/C108H140Cl2N26O31/c1-7-51(2)16-12-10-8-9-11-13-19-77(145)122-75(46-79(147)148)95(155)130-82-55(6)167-105(165)88(60-28-38-68(144)39-29-60)136-90(150)52(3)119-93(153)73(44-62-47-117-106(112)120-62)123-78(146)49-116-97(157)87(61-42-69(109)89(149)70(110)43-61)132-96(156)76(50-137)127-102(162)83(56-20-30-64(140)31-21-56)131-94(154)74(45-63-48-118-107(113)121-63)126-91(151)72(18-15-41-115-108(114)166)124-98(158)80(53(4)138)129-103(163)85(58-24-34-66(142)35-25-58)135-104(164)86(59-26-36-67(143)37-27-59)133-99(159)81(54(5)139)128-92(152)71(17-14-40-111)125-101(161)84(134-100(82)160)57-22-32-65(141)33-23-57/h9,11,13,19-39,42-43,51-55,62-63,71-76,80-88,137-144,149H,7-8,10,12,14-18,40-41,44-50,111H2,1-6H3,(H,116,157)(H,119,153)(H,122,145)(H,123,146)(H,124,158)(H,125,161)(H,126,151)(H,127,162)(H,128,152)(H,129,163)(H,130,155)(H,131,154)(H,132,156)(H,133,159)(H,134,160)(H,135,164)(H,136,150)(H,147,148)(H3,112,117,120)(H3,113,118,121)(H3,114,115,166)/b11-9+,19-13-/t51?,52-,53+,54-,55-,62-,63-,71-,72+,73+,74-,75+,76-,80+,81-,82+,83+,84-,85-,86+,87+,88+/m1/s1. InChi Key: JPYWPHBUMZRLPO-DLYWSANHSA-N.