Clofazimine

Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 µg/ml against clinical isolates of M. paratuberculosis. It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = =0.25-8 µg/ml). Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL. Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.Formal Name: N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-2-phenazinamine. CAS Number: 2030-63-9. Synonyms: NSC 141046. Molecular Formula: C27H22Cl2N4. Formula Weight: 473.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 1 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 285, 452 nm. SMILES: CC(C)/N=C1C=C2N(C3=CC=C(Cl)C=C3)C4=CC=CC=C4N=C2C=C\1NC5=CC=C(Cl)C=C5. InChi Code: InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+. InChi Key: WDQPAMHFFCXSNU-BGABXYSRSA-N.