Cellocidin

Cellocidin is an antibiotic originally isolated from S. chibaensis. It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC50s = 150 and 30 ng/ml, respectively). It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-kappaB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus. Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits alpha-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle.Formal Name: 2-butynediamide. CAS Number: 543-21-5. Synonyms: Acetylenedicarboxylic Acid, NSC 38643, NSC 65381. Molecular Formula: C4H4N2O2. Formula Weight: 112.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml. lambdamax: 212 nm. SMILES: NC(C#CC(N)=O)=O. InChi Code: InChI=1S/C4H4N2O2/c5-3(7)1-2-4(6)8/h(H2,5,7)(H2,6,8). InChi Key: JBTGHKUTYAMZEZ-UHFFFAOYSA-N.