Ceftizoxime (sodium salt)

Ceftizoxime is a cephalosporin antibiotic. Ceftizoxime is active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, and S. epidermidis (IC50s = 1.56, =0.025, and 0.78 µg/ml, respectively), as well as clinical isolates of the Gram-negative bacteria E. coli, K. pneumoniae, and P. mirabilis (IC50s = 0.1, =0.025, and =0.025 µg/ml, respectively). It is protective against S. aureus, E. coli, P. mirabilis, or P. vulgaris infection in mice (ED50s = 4.03, 0.02, 0.255, and 0.038 mg/kg, respectively). Formulations containing ceftizoxime have been used in the treatment of a variety of bacterial infections.Formal Name: 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt. CAS Number: 68401-82-1. Synonyms: FR 13479. Molecular Formula: C13H12N5O5S2 . Na. Formula Weight: 405.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: 3 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 230 nm. SMILES: [H][C@]12SCC=C(C([O-])=O)N1C([C@H]2NC(/C(C3=CSC(N)=N3)=N\OC)=O)=O.[Na+]. InChi Code: InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18,/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22),/q,+1/p-1/b17-7-,/t8-,11-,/m1./s1. InChi Key: ADLFUPFRVXCDMO-LIGXYSTNSA-M.