Cefradine

Cefradine is an orally bioavailable beta-lactam cephalosporin antibiotic. It is active against S. pyogenes, E. coli, K. pneumoniae, and E. cloacae (MICs = 0.04, 9.4, 9.4, and 6.3 µg/ml, respectively). Cefradine is also active against clinical isolates of S. aureus (MICs = 0.8-6 µg/ml) and S. pyogenes (MICs = 0.1-0.4 µg/ml), as well as H. influenzae, E. coli, and K. pneumoniae (MICs = 6.2-12.5 µg/ml). It increases survival in mouse models of systemic lethal infection by S. pyogenes, E. coli, K. pneumoniae, or E. cloacae (ED50s = 5, 37, 122, and 50 mg/kg, respectively), as well as by penicillin-susceptible or -resistant strains of S. aureus (ED50s = 18 and 91 mg/kg, respectively). Formulations containing cefradine have previously been used in the treatment of respiratory and urinary tract infections, skin infections, and otitis media.Formal Name: (6R,7R)-7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. CAS Number: 38821-53-3. Synonyms: SQ 11,436. Molecular Formula: C16H19N3O4S. Formula Weight: 349.4. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 263 nm. SMILES: O=C(N[C@@H]1C(N2[C@]1([H])SCC(C)=C2C(O)=O)=O)[C@H](N)C3=CCC=CC3. InChi Code: InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1. InChi Key: RDLPVSKMFDYCOR-UEKVPHQBSA-N.