Capreomycin (sulfate)

Capreomycin is a polypeptide antibiotic originally isolated from S. capreolus. It is active against M. tuberculosis (MIC = 10 µg/ml). Capreomycin binds to both the 30S and 50S ribosomal subunits, inhibiting protein synthesis. It increases survival and decreases lung necrosis in mice infected with the streptomycin-resistant M. tuberculosis strain H37Rv when administered at doses ranging from 50 to 500 mg/kg. Formulations containing capreomycin have been used in the treatment of multidrug-resistant tuberculosis.Formal Name: (2S)-2,5-diamino-N-(((2S,5R,11S,15R,Z)-15-amino-11-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-8-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-5-yl)methyl)pentanamide, monosulfate. CAS Number: 1405-37-4. Molecular Formula: C24H42N14O8 . H2SO4. Formula Weight: 752.8. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Water: 50 mg/ml. SMILES: O=C(NC[C@H](C(N/C(C(N[C@@H](C1NC(N)=NCC1)C(NC[C@H]2N)=O)=O)=C\NC(N)=O)=O)NC([C@H](CO)NC2=O)=O)[C@@H](N)CCCN.O=S(O)(O)=O. InChi Code: InChI=1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13,1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41. InChi Key: LFFNIXQXRKNZCE-UBBQZPMLSA-N.