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Bleomycin is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. Its... more
Product information "Bleomycin (sulfate)"
Bleomycin is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. Its mechanism of action causes single- and double-strand DNA breaks in tumor cells, which interrupts the cell cycle. Bleomycin is thought to achieve this by chelating metal ions, producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. Bleomycin has been used for the treatment of Hodgkin's lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis.{21618, 21616}Formal Name: bleomycin sulfate (salt). CAS Number: 9041-93-4. Synonyms: Blenoxane. Molecular Formula: C55H84N17O21S3 . XHSO4 (for A2). Formula Weight: 1415.6. Purity: >95% (mixture of A2 and B2). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 13 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 294 nm. SMILES: NC(C[C@H](NC[C@H](N)C(N)=O)C1=NC(N)=C(C)C(C(N[C@H](C(N[C@@H]([C@H]([C@H](C)C(N[C@@H]([C@@H](C)O)C(NCCC2=NC(C3=NC(C(NCCC[S+](C)C)=O)=CS3)=CS2)=O)=O)O)C)=O)C(O[C@@H]4O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)C6=CNC=N6)=O)=N1)=O.O=S(O)([O-])=O. InChi Code: InChI=1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6,1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88),(H2,1,2,3,4)/t21-,22+,23+,24-,25-,29-,30+,34-,35-,36-,37+,38+,39-,40-,41?,42-,43-,53+,54-,/m0./s1. InChi Key: WUIABRMSWOKTOF-VXXHAVRASA-N.
Keywords: | Blenoxane, bleomycin sulfate (salt) |
Supplier: | Cayman Chemical |
Supplier-Nr: | 13877 |
Properties
Application: | Apoptosis inducer |
MW: | 1415.6 D |
Formula: | C55H84N17O21S3 . XHSO4 (A2) |
Purity: | >95% (mixture of A2 and B2) |
Format: | Crystalline Solid |
Database Information
CAS : | 9041-93-4| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H340, H351, H361 |
P Phrases: | P201, P202, P280, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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