Amikacin disulfate salt

RTECS: WK1961200 Source/Host Chemicals: Synthetic. Purity Chemicals: >97% (NMR) Appearance: White to off-white powder. Solubility: Soluble in water (50mg/ml). Identity: Determined by 1H-NMR. InChi Key: FXKSEJFHKVNEFI-GCZBSULCSA-N Smiles: OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]([C@@H]([C@H]1N)O[C@H]([C@@H]([C@H]2O)O)O[C@H](CN)[C@H]2O)[C@H]([C@@H](C1)N([H])C([C@H](CCN)O)=O)O[C@H]([C@@H]([C@H]3N)O)O[C@H](CO)[C@H]3O Amikacin is a broad-spectrum aminoglycoside antibiotic and a semisynthetic analog of kanamycin. It irreversibly binds to 16S rRNA and the RNA-binding S12 protein of the 30S subunit and 50S subunit of prokaryotic ribosome and inhibits protein synthesis. It works in a concentration-dependent manner, and has better action in an alkaline environment. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains, due to its resistance to inactivating enzymes. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin can be used to treat non-tubercular mycobacterial infections and tuberculosis when first-line drugs fail to control the infection. Product References [1] H. Kawaguchi, et al., J. Antibiot. 25, 695 (1972) , [2] P.K. Yu, et al., Antimicrob. Agents Chemother. 4, 133 (1973) , [3] D. Zaske & K. Crossley, Minn. Med. 61, 123 (1978) (Review) , [4] F.D. Pien & P.W. Ho, Am. J. Hosp. Pharm. 38, 981 (1981) (Review) , [5] A.M. Ristuccia & B.A.Cunha, Ther. Drug Monit. 7, 12 (1985) (Review) , [6] M.S. Ramirez & M.E. Tolmasky, Molecules 22, 2267 (2017) (Review)