Actinopyrone A

Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities. It has selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis. Actinopyrone A also mildly inhibits growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 µg/mL. Intravenous administration of actinopyrone A (30 µg/kg) increases coronary blood flow in dogs by 196.2%.Formal Name: 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one. CAS Number: 88378-59-0. Synonyms: (+)-Actinopyrone A, SS 1538A. Molecular Formula: C25H36O4. Formula Weight: 400.6. Purity: >95%. Formulation: (Request formulation change), An oil. SMILES: COC1=C(C)C(C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@@H](C)[C@@H](O)/C(C)=C/C)O1)=O. InChi Code: InChI=1S/C25H36O4/c1-9-18(4)23(26)19(5)15-17(3)12-10-11-16(2)13-14-22-20(6)24(27)21(7)25(28-8)29-22/h9-10,12-13,15,19,23,26H,11,14H2,1-8H3/b12-10+,16-13+,17-15+,18-9+/t19-,23+/m1/s1. InChi Key: PFVSUJLJFXJPMF-DNSWMBNWSA-N.