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Tunicamycin Mixture
Item number: Cay11445-10
Tunicamycin mixture is a mixture of tunicamycins with variable trans-2,3-unsaturated branched chain fatty acid (BFCA) chain lengths. Tunicamycins are anti-microbial agents that are active against Gram-positive bacteria, fungi, and viruses. They inhibit the N-acetylhexosamine (HexNAc) phosphotransferase family of...
| Application: | N-glycosylation inhibitor |
| CAS | 11089-65-9 |
| MW: | 845 D |
From 60.00€
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Mitomycin C
Item number: Cay11435-5
Mitomycin C (MMC) is an antitumor antibiotic that was discovered as a fermentation product of S. caespitosus. As an alkylating agent, its activity depends on reductive activation either through low pH or DT-diaphorase or NADH cytochrome c reductase. Activated MMC crosslinks double stranded DNA and is widely used as...
| Keywords: | Ametycine, MitoExtra, Mitonco, Mitoplus, MMC, NSC 26980,... |
| Application: | Antitumor antibiotic |
| CAS | 50-07-7 |
| MW: | 334.3 D |
From 101.00€
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Rapamycin
Item number: AG-CN2-0025-M001
Isolated from Streptomyces hygroscopicus. Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an...
| Keywords: | Sirolimus, Rapamune, NSC 226080, Antibiotic AY-22989, WY-090217, RAPA, SILA 9268A, CCRIS 9024 |
| Application: | mTOR inhibitor, Immunsuppressant, Apoptosis inducer |
| CAS | 53123-88-9 |
| MW: | 914,2 D |
From 28.00€
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Oligomycin Complex
Item number: Cay11341-5
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins...
| Application: | ATP synthase inhibitor, Apoptosis inducer |
| CAS | 1404-19-9 |
| MW: | 789,3 D |
From 60.00€
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(+)-Aphidicolin
Item number: Cay14007-5
(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases alpha, delta, and...
| Keywords: | ICI 69653, NSC 234714,... |
| Application: | Eucaryotic nuclear DNA replication inhibitor |
| CAS | 38966-21-1 |
| MW: | 338.5 D |
From 147.00€
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Actinomycin D
Item number: Cay11421-5
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate. DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low...
| Keywords: | Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K,... |
| Application: | Cancer studies, antineoplastic |
| CAS | 50-76-0 |
| MW: | 1255.5 D |
From 107.00€
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Spiramycin
Item number: LKT-S6232.5
A macrolide antibiotic. It has been shown to decrease the replication index of humanlymphocytes.
| Keywords: | SPM, RP-5337 |
| Application: | Antibiotic, macrolide |
| CAS | 8025-81-8 |
| MW: | 842,05 D |
From 144.00€
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Gentamycin (Gentamicin) Sulfate Solution 50mg/ml...
Item number: G2032.20
Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. Inhibits growth of gram positive and negative bacteria, and mycoplasma. Inhibits normal protein synthesis by binding to L6 protein of 50S ribosomal subunit. Useful antibiotic for Baculovirus expression...
| CAS | 1405-41-0 |
From 151.00€
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Vancomycin (hydrochloride)
Item number: Cay15327-1
Vancomycin is a glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci. It acts by binding to bacterial cell wall protein precursors, interfering with continuing protein synthesis. Vancomycin resistance in staphylococcal species has...
| Keywords: | Lyphocin, Vancomycin hydrochloride |
| Application: | Antibiotic |
| CAS | 1404-93-9 |
| MW: | 1449.3 D |
From 91.00€
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G418, sulfate
Item number: AG-CN2-0030-G005
Isolated from Micromonospora rhodorangea. Antibiotic. Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis. Apoptosis inducer. Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II. Antiviral. Assay:...
| Keywords: | Geneticin, Antibiotic G418, BRN 1669188 |
| Application: | Apoptosis inducer |
| CAS | 108321-42-2 |
From 36.00€
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Leptomycin B
Item number: Cay10004976-5
Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear...
| Keywords: | Elactocin, LMB, Mantuamycin, NSC 364372,... |
| Application: | Nuclear export blocker |
| CAS | 87081-35-4 |
| MW: | 540.7 D |
From 60.00€
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Ampicillin (sodium salt)
Item number: Cay14417-25
Ampicillin is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative bacteria, including veterinary isolates of S. pseudintermedius, S. aureus, E. coli, Pasteurella, and S. canis (MIC50s = 0.25, 0.5, 2, 0.12, and 0.25 µg/ml, respectively). In vivo, ampicillin (80 mg/kg, i.v.) reduces cough...
| Keywords: | (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,... |
| Application: | Antibiotic |
| CAS | 69-52-3 |
| MW: | 371.4 D |
From 76.00€
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