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8-iso Prostaglandin F2alpha
Item number: Cay16350-1
8-iso PGF2alpha is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2alpha...
| Keywords: | 15-F2t-Isoprostane, 8-epi PGF2alpha, 8-iso-15(S)-Prostaglandin F2alpha, 8-Isoprostane, iPF2alpha-III,... |
| Application: | TP receptor agonist |
| CAS | 27415-26-5 |
| MW: | 354.5 D |
From 269.00€
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DAPT
Item number: Cay13197-5
gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...
| Keywords: | GSI-IX, N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine, 1,1-dimethylethyl ester |
| Application: | gamma-secretase inhibitor |
| CAS | 208255-80-5 |
| MW: | 432.5 D |
From 91.00€
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Fura-2, AM *Bulk packaging*
Item number: ABD-21020
Fura-2, AM is a cell-permeable calcium indicator that is emission-ratiometric and UV light excitable. This AM ester form can be loaded into live cells noninvasively.
| Application: | Calcium indicator |
| CAS | 108964-32-5 |
From 145.00€
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SU 5416
Item number: Cay13342-50
SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2, FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 µM), SU 5416 also inhibits PDGFR (IC50 = 20 µM),...
| Keywords: | NSC 696819, Semaxinib, Sugen 5416, VEGFR 2 Kinase Inhibitor,... |
| Application: | Tyrosine kinase inhibitor |
| CAS | 204005-46-9 |
| MW: | 238.3 D |
From 198.00€
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Doxorubicin (hydrochloride)
Item number: Cay15007-5
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...
| Keywords: | DOX,... |
| Application: | DNA topoisomerase II inhibitor, antitumor agent |
| CAS | 25316-40-9 |
| MW: | 580 D |
From 60.00€
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LY294002
Item number: Cay70920-5
LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta...
| Keywords: | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| Application: | PI3K inhibitor |
| CAS | 154447-36-6 |
| MW: | 307.3 D |
From 44.00€
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ALK5 Inhibitor II
Item number: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Keywords: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| Application: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.3 D |
From 45.00€
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Fumonisin B1
Item number: Cay62580-5
Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces...
| Keywords: | FB1, (2R,2'R)-1,2,3-propanetricarboxylic acid,... |
| Application: | Ceramide synthase inhibitor |
| CAS | 116355-83-0 |
| MW: | 721.8 D |
From 120.00€
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15-deoxy-Delta12,14-Prostaglandin J2
Item number: Cay18570-1
15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating...
| Keywords: | 15-deoxy-Delta12,14-PGJ2, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 87893-55-8 |
| MW: | 316.4 D |
From 55.00€
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Ampicillin, sodium salt
Item number: 01503.25
Crystalline, H2O: <2%, It is effective against gram-positive and some gram-negative bacteria, inhibiting cell wall synthesis.
| Application: | Antibiotic |
| CAS | 69-52-3 |
| MW: | 371.39 |
68.00€
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SAHA
Item number: Cay10009929-100
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name:...
| Keywords: | Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide |
| Application: | HDAC inhibitor |
| CAS | 149647-78-9 |
| MW: | 264.3 D |
From 74.00€
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Erastin
Item number: Cay17754-5
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
| Keywords: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
| Application: | Antitumor agent |
| CAS | 571203-78-6 |
| MW: | 547.1 D |
From 76.00€
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