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(S)-MG132
Item number: Cay10012628-5
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle...
| Keywords: | Z-Leu-Leu-Leu-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Application: | Proteasome inhibitor |
| CAS | 133407-82-6 |
| MW: | 475.6 D |
From 38.00€
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Rapamycin
Item number: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
| Keywords: | AY 22989, NSC 226080, Wy 090217,... |
| Application: | mTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
From 58.00€
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Prostaglandin F2alpha
Item number: Cay16010-10
Prostaglandin F2alpha (PGF2alpha) is a widely distributed PG occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. PGF2alpha exerts its receptor mediated physiological activity at 50-100 nM. Maximal ovine...
| Keywords: | Dinoprost, PGF2alpha, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 551-11-1 |
| MW: | 354.5 D |
From 68.00€
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Altertoxin I
Item number: Cay21129-1
Altertoxin I is a natural mycotoxin first isolated from fungi of the genus Alternaria. It is a hydroxyperylenequinone that shows mutagenic activity against S. typhimurium and inhibits human topoisomerase II and bacterial gyrase. Altertoxin I completely inhibits replication of HIV-1 virus at 2.2 µM in a cell-based...
| Keywords: | Dihydroalterperylenol, (1S,12aR,12bS)-1,2,11,12,12a,12b-hexahydro-1,4,9,12a-tetrahydroxy-3,10-perylenedione |
| Application: | Mycotoxin |
| CAS | 56258-32-3 |
| MW: | 352.3 D |
From 471.00€
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Rosiglitazone
Item number: Cay71740-10
Rosiglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma1 and PPARgamma2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARgamma over PPARalpha and...
| Keywords: | BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Application: | PPARgamma agonist |
| CAS | 122320-73-4 |
| MW: | 357.4 D |
From 53.00€
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Peroxynitrite
Item number: Cay81565-1
Peroxynitrite is formed in vivo by the reaction of NO with superoxide. It is a powerful oxidizing agent that can initiate lipid peroxidation, oxidize sulfhydryls, and nitrate the aromatic residues of proteins.Formal Name: peroxynitrous acid, sodium salt. CAS Number: 14042-01-4. Synonyms: Sodium Peroxynitrite....
| Keywords: | Sodium Peroxynitrite, peroxynitrous acid, sodium salt |
| Application: | Oxidizing agent |
| CAS | 14042-01-4 |
| MW: | 85 D |
97.00€
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Chromomycin A3
Item number: Cay11315-5
Chromomycin A3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in...
| Keywords: | Aburamycin B, CMA3, NSC 58514,... |
| Application: | FC, GC base pair fluorescent probe |
| CAS | 7059-24-7 |
| MW: | 1183.3 D |
From 77.00€
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(±)9-HODE
Item number: Cay38400-100
(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in mitochondrial and plasma membranes of rabbit reticulocytes. Oxidized LDL contains significant amounts of esterified 9- and 13-HpODEs...
| Keywords: | (±)-9-hydroxy-10E,12Z-octadecadienoic acid |
| Application: | Bioactive lipid studies |
| CAS | 98524-19-7 |
| MW: | 296.5 D |
From 216.00€
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Phalloidin-iFluor(TM) 647 Conjugate
Item number: ABD-23127
This deep red fluorescent phalloidin conjugate (equivalent to Alexa Fluor(R) 633-labeled phalloidin) selectively binds to F-actins. Used at nanomolar concentrations, phalloidin derivatives are convenient probes for labeling, identifying and quantitating F-actins in formaldehyde-fixed and permeabilized tissue...
| Application: | Labeling |
| MW: | 2,20 kD |
218.00€
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Resolvin D1
Item number: Cay10012554-10
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1) is produced...
| Keywords: | 17(S)-Resolvin D1, RvD1, 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 872993-05-0 |
| MW: | 376.5 D |
From 228.00€
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Arachidonic Acid-d8
Item number: Cay390010-1
Arachidonic acid-d8 is intended for use as an internal standard for the quantification of arachidonic acid (Cay-90010) by GC- or LC-MS. Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane...
| Keywords: | AA-d8, 5Z,8Z,11Z,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| Application: | Standard |
| CAS | 69254-37-1 |
| MW: | 312.5 D |
From 192.00€
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Eicosapentaenoic Acid
Item number: Cay90110-50
EPA is an omega-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some...
| Keywords: | EPA, Timnodonic Acid, 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 10417-94-4 |
| MW: | 302.5 D |
From 57.00€
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