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Lipid-based Drug Delivery Tools
Sphingosine-1-phosphate (d18:1)
Item number: Cay62570-1
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...
| Keywords: | S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate) |
| Application: | Bioactive lipid assays |
| CAS | 26993-30-6 |
| MW: | 379.5 D |
From 122.00€
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L-NIL (hydrochloride)
Item number: Cay80310-10
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection...
| Keywords: | N6-(1-iminoethyl)-L-lysine, dihydrochloride |
| Application: | iNOS inhibitor |
| CAS | 159190-45-1 |
| MW: | 260.2 D |
From 85.00€
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DETA NONOate
Item number: Cay82120-10
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.Formal Name:...
| Keywords: | Diethylenetriamine NONOate, NOC-18, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate |
| Application: | NO donor |
| CAS | 146724-94-9 |
| MW: | 163.2 D |
From 60.00€
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Disuccinimidyl Sulfoxide
Item number: Cay9002863-50
Disuccinimidyl sulfoxide (DSSO) is a protein cross-linking probe designed to be used with mass spectrometry (MS). It contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns. The...
| Keywords: | DSSO, 3,3'-sulfinylbis-propanoic acid, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester |
| Application: | Protein cross-linking probe |
| CAS | 1351828-03-9 |
| MW: | 388.3 D |
From 76.00€
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Nitisinone
Item number: LKT-N3476.50
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
| Keywords: | NTBC, orfadin |
| Application: | 4-hydroxyphenylpyruvate dioxygenase inhibitor |
| CAS | 104206-65-7 |
| MW: | 329.23 D |
From 85.00€
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Ionomycin
Item number: Cay10004974-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Keywords: | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro... |
| Application: | Ca Ionophore |
| CAS | 56092-81-0 |
| MW: | 709 D |
From 76.00€
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Prostaglandin D2
Item number: Cay12010-1
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via...
| Keywords: | PGD2, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 41598-07-6 |
| MW: | 352.5 D |
From 85.00€
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PF-8380
Item number: Cay12018-25
Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay), the enzyme that converts lysophosphatidylcholine to lysophosphatidic acid...
| Keywords: | 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid |
| Application: | Autotaxin Inhibitor |
| CAS | 1144035-53-9 |
| MW: | 478.3 D |
From 74.00€
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SB-431542 (hydrate)
Item number: Cay13031-10
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
| Keywords: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
| Application: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| MW: | 384.4 D |
From 55.00€
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Compound E
Item number: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
| Keywords: | gamma-Secretase Inhibitor XXI,... |
| Application: | gamma-Secretase inhibitor |
| CAS | 209986-17-4 |
| MW: | 490.5 D |
From 290.00€
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(±)14(15)-EET
Item number: Cay50651-50
(±)14(15)-EET is a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450. It prevents increases in leukotriene B4 (LTB4, Cay-20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary...
| Keywords: | (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| CAS | 197508-62-6 |
| MW: | 320.5 D |
From 85.00€
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DMOG
Item number: Cay71210-100
The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1alpha prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1alpha...
| Keywords: | Dimethyloxallyl Glycine, N-(methoxyoxoacetyl)-glycine, methyl ester |
| Application: | HIF-PH inhibitor |
| CAS | 89464-63-1 |
| MW: | 175.1 D |
From 40.00€
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