No results were found for the filter!
Ionomycin
Item number: Cay10004974-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Keywords: | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro... |
| Application: | Ca Ionophore |
| CAS | 56092-81-0 |
| MW: | 709 D |
From 73.00€
*
2-NBDG
Item number: Cay11046-1
2-NBDG is a fluorescent derivative of glucose whose uptake is competitively inhibited by D-glucose (Cay-23733), but not L-glucose (Cay-20829) or sucrose, in E. coli. It has been used to monitor glucose uptake by bacteria and live mammalian cells and in tumor biopsies. 2-NBDG displays excitation/emission maxima of...
| Keywords: | NBD-Glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose |
| Application: | Deoxyglucose analog |
| CAS | 186689-07-6 |
| MW: | 342.3 D |
From 68.00€
*
Prostaglandin D2
Item number: Cay12010-1
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via...
| Keywords: | PGD2, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 41598-07-6 |
| MW: | 352.5 D |
From 83.00€
*
PF-8380
Item number: Cay12018-25
Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay), the enzyme that converts lysophosphatidylcholine to lysophosphatidic acid...
| Keywords: | 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid |
| Application: | Autotaxin Inhibitor |
| CAS | 1144035-53-9 |
| MW: | 478.3 D |
From 72.00€
*
SB-431542 (hydrate)
Item number: Cay13031-10
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
| Keywords: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
| Application: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| MW: | 384.4 D |
From 53.00€
*
Compound E
Item number: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
| Keywords: | gamma-Secretase Inhibitor XXI,... |
| Application: | gamma-Secretase inhibitor |
| CAS | 209986-17-4 |
| MW: | 490.5 D |
From 281.00€
*
(±)14(15)-EET
Item number: Cay50651-50
(±)14(15)-EET is a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450. It prevents increases in leukotriene B4 (LTB4, Cay-20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary...
| Keywords: | (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| CAS | 197508-62-6 |
| MW: | 320.5 D |
From 83.00€
*
DMOG
Item number: Cay71210-100
The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1alpha prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1alpha...
| Keywords: | Dimethyloxallyl Glycine, N-(methoxyoxoacetyl)-glycine, methyl ester |
| Application: | HIF-PH inhibitor |
| CAS | 89464-63-1 |
| MW: | 175.1 D |
From 38.00€
*
Calcitriol
Item number: Cay71820-1
Calcitriol is a vitamin D3 receptor agonist and active metabolite of vitamin D3 (Cay-11792). It is formed via a multi-step process, in which vitamin D3 undergoes hydroxylation to 25-hydroxy vitamin D3 (Cay-9000683) in the liver, followed by further hydroxylation at the 1alpha-position in the kidney. Calcitriol binds...
| Keywords: | 1alpha,25-dihydroxy Vitamin D3, 9,10-secocholesta-5Z,7E,10(19)-triene-1alpha,3beta,25-triol |
| Application: | Metabolic studies |
| CAS | 32222-06-3 |
| MW: | 416.6 D |
From 133.00€
*
Arachidonic Acid
Item number: Cay90010-100
Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient,...
| Keywords: | AA, 5Z,8Z,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 506-32-1 |
| MW: | 304.5 D |
From 53.00€
*
Fura-2, AM *UltraPure grade*
Item number: ABD-21021
20 x 50 µg. Fura-2, AM is a cell-permeable calcium indicator that is emission-ratiometric and UV light excitable. This AM ester form can be loaded into live cells noninvasively.
| Application: | Calcium indicator |
| CAS | 108964-32-5 |
From 218.00€
*
Phorbol 12-myristate 13-acetate
Item number: Cay10008014-1
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. It activates the PKC isoforms PKCalpha, -beta, -gamma, -delta, -epsilon, -eta, and -theta but not PKCzeta or -iota/lambda. PMA (1-10 ng/ml) induces NF-kappaB-dependent gene...
| Keywords: | 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA, tetradecanoic acid,... |
| Application: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616.8 D |
From 58.00€
*