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Metformin (hydrochloride)
Item number: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
| Keywords: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Application: | AMPK activator |
| CAS | 1115-70-4 |
| MW: | 165.6 D |
From 44.00€
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Hygromycin B (hydrate)
Item number: Cay14291-1
Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 µg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for...
| Keywords: | O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N3-methyl-D-strep... |
| Application: | Antibiotic |
| MW: | 527.5 D |
From 131.00€
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FCCP
Item number: Cay15218-10
FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 µM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the...
| Keywords: | Trifluoromethoxy carbonylcyanide phenylhydrazone, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile |
| Application: | Inhibits mitochondrial oxidative phosphorylation, uncoupling reagent |
| CAS | 370-86-5 |
| MW: | 254.2 D |
From 108.00€
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Ganglioside GT1b (bovine) (sodium salt)
Item number: Cay15588-5
Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 µM, respectively. Ganglioside GT1b-containing...
| Keywords: | Ganglioside G1 Mixture |
| Application: | Trisialoganglioside |
| MW: | 2126.3 D |
From 192.00€
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Leukotriene B4
Item number: Cay20110-25
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar...
| Keywords: | LTB4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 71160-24-2 |
| MW: | 336.5 D |
From 221.00€
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(±)5(6)-EET
Item number: Cay50211-50
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior...
| Keywords: | (±)5,6-EpETrE, (±)5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| CAS | 87173-80-6 |
| MW: | 320.5 D |
From 68.00€
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(±)8(9)-EET
Item number: Cay50351-50
(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010). (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARalpha in HEK293 cells when used at a concentration of 1 µM but inhibits NF-kappaB activity induced by...
| Keywords: | (±)8,9-EpETrE, (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid |
| Application: | Bioactive lipid assays |
| MW: | 320.5 D |
From 58.00€
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Lipid-based Drug Delivery Tools
Sphingosine-1-phosphate (d18:1)
Item number: Cay62570-1
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...
| Keywords: | S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate) |
| Application: | Bioactive lipid assays |
| CAS | 26993-30-6 |
| MW: | 379.5 D |
From 118.00€
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L-NIL (hydrochloride)
Item number: Cay80310-10
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection...
| Keywords: | N6-(1-iminoethyl)-L-lysine, dihydrochloride |
| Application: | iNOS inhibitor |
| CAS | 159190-45-1 |
| MW: | 260.2 D |
From 83.00€
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DETA NONOate
Item number: Cay82120-10
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.Formal Name:...
| Keywords: | Diethylenetriamine NONOate, NOC-18, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate |
| Application: | NO donor |
| CAS | 146724-94-9 |
| MW: | 163.2 D |
From 58.00€
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Disuccinimidyl Sulfoxide
Item number: Cay9002863-50
Disuccinimidyl sulfoxide (DSSO) is a protein cross-linking probe designed to be used with mass spectrometry (MS). It contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns. The...
| Keywords: | DSSO, 3,3'-sulfinylbis-propanoic acid, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester |
| Application: | Protein cross-linking probe |
| CAS | 1351828-03-9 |
| MW: | 388.3 D |
From 73.00€
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Nitisinone
Item number: LKT-N3476.50
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
| Keywords: | NTBC, orfadin |
| Application: | 4-hydroxyphenylpyruvate dioxygenase inhibitor |
| CAS | 104206-65-7 |
| MW: | 329.23 D |
From 85.00€
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