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Y-27632 (hydrochloride)
Item number: Cay10005583-10
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50...
| Keywords: | 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide, dihydrochloride |
| Application: | ROCK inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.3 D |
From 87.00€
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Cytochalasin D
Item number: Cay11330-1
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
| Keywords: | NSC 209835,... |
| Application: | Cell-permeable actin polymerization inhibitor |
| CAS | 22144-77-0 |
| MW: | 507.6 D |
From 103.00€
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Ionomycin (calcium salt)
Item number: Cay11932-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Keywords: | 11,19R,21S-trihydroxy-4R,6S,8S,12R,14R,18R,20S-heptamethyl-22-[octahydro-5'S-[1R-hydroxyethyl]-2S,5'-dimethyl[2,2'R-bifura... |
| Application: | Calcium ionophore |
| CAS | 56092-82-1 |
| MW: | 747.1 D |
From 58.00€
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CHIR99021
Item number: Cay13122-10
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...
| Keywords: | CT 99021,... |
| Application: | GSK3alpha and GSK3beta inhibitor |
| CAS | 252917-06-9 |
| MW: | 465.3 D |
From 53.00€
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Prostaglandin E2
Item number: Cay14010-1
PGE2 is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors...
| Keywords: | Dinoprostone, PGE2, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 363-24-6 |
| MW: | 352.5 D |
From 44.00€
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Calcein AM
Item number: Cay14948-1
Calcein AM is a cell-permeable dye that, upon entering live cells, is cleaved by intracellular esterases, leaving membrane-impermeant calcein (Cay-16221), a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively. It can be used as an indicator of cell viability, cell-cell...
| Keywords: | Calcein Acetoxymethyl ester, NSC 689290,... |
| Application: | Cell-permeable dye, cell viability assays |
| CAS | 148504-34-1 |
| MW: | 994.9 D |
From 116.00€
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U-46619
Item number: Cay16450-1
U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist. It exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0,...
| Keywords: | 9,11-dideoxy-9alpha,11alpha-methanoepoxy PGF2alpha, 9,11-dideoxy-9alpha,11alpha-methanoepoxy Prostaglandin F2alpha,... |
| Application: | TP receptor agonist |
| CAS | 56985-40-1 |
| MW: | 350.5 D |
From 147.00€
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Thapsigargin
Item number: Cay10522-1
Thapsigargin is an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = ~30 nM for the rat liver microsomal enzyme), an ER stress inducer, and a sesquiterpene lactone that has been found in Thapsia. It increases intracellular calcium levels in isolated rat hepatocytes (EC50 = ~80 nM) and...
| Keywords: | (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a... |
| Application: | SERCA inhibitor |
| CAS | 67526-95-8 |
| MW: | 650.8 D |
From 89.00€
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Bluo-Gal, pure
Item number: 50375.1
5-Bromo-3-Indolyl-ß-D-Galactopyranoside (Bluo-Gal) is a substrate for the histochemical localization of ß-galactosidase. Bluo-Gal is an alternative to X-Gal, producing a darker blue color.
| Keywords: | 5-Bromo-3-indolyl beta-D-galactopyranoside |
| Application: | beta-Galactosidase substrate |
| CAS | 97753-82-7 |
| MW: | 374.20 |
295.00€
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Bicine, ultra pure
Item number: 01848.500
Bicine is an organic buffering agent. It is one of Good's buffers and has a pKa of 8.35 at 20°C. It is prepared by the reaction of glycine with ethylene oxide, followed by hydrolysis of the resultant lactone. Useful pH range: 7.8-8.8
| CAS | 150-25-4 |
| MW: | 163.17 |
From 138.00€
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NADH, disodium salt
Item number: 16132.1
Assay: >85% enzymatically
| Keywords: | beta-Nicotinamide-adenine-dinucleotide, reduced Na2-salt |
| CAS | 606-68-8 |
| MW: | 709.4 D |
From 105.00€
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(Ac-ANW)2R110
Item number: ABD-13455
(Ac-ANW)2R110 is a selective fluorogenic substrate for proteasome 20S-beta 5i. The non-fluorescent substrate generates a bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set.
| Application: | Proteasome 20S-beta 5i substrate |
291.00€
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