No results were found for the filter!
Y-27632 (hydrochloride)
Item number: Cay10005583-10
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50...
| Keywords: | 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide, dihydrochloride |
| Application: | ROCK inhibitor |
| CAS | 129830-38-2 |
| MW: | 320.3 D |
From 90.00€
*
Cytochalasin D
Item number: Cay11330-1
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
| Keywords: | NSC 209835,... |
| Application: | Cell-permeable actin polymerization inhibitor |
| CAS | 22144-77-0 |
| MW: | 507.6 D |
From 107.00€
*
Ionomycin (calcium salt)
Item number: Cay11932-1
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...
| Keywords: | 11,19R,21S-trihydroxy-4R,6S,8S,12R,14R,18R,20S-heptamethyl-22-[octahydro-5'S-[1R-hydroxyethyl]-2S,5'-dimethyl[2,2'R-bifura... |
| Application: | Calcium ionophore |
| CAS | 56092-82-1 |
| MW: | 747.1 D |
From 60.00€
*
2-NBDG
Item number: Cay11046-1
2-NBDG is a fluorescent derivative of glucose whose uptake is competitively inhibited by D-glucose (Cay-23733), but not L-glucose (Cay-20829) or sucrose, in E. coli. It has been used to monitor glucose uptake by bacteria and live mammalian cells and in tumor biopsies. 2-NBDG displays excitation/emission maxima of...
| Keywords: | NBD-Glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose |
| Application: | Deoxyglucose analog |
| CAS | 186689-07-6 |
| MW: | 342.3 D |
From 70.00€
*
CHIR99021
Item number: Cay13122-10
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...
| Keywords: | CT 99021,... |
| Application: | GSK3alpha and GSK3beta inhibitor |
| CAS | 252917-06-9 |
| MW: | 465.3 D |
From 55.00€
*
Prostaglandin E2
Item number: Cay14010-1
PGE2 is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors...
| Keywords: | Dinoprostone, PGE2, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 363-24-6 |
| MW: | 352.5 D |
From 45.00€
*
Calcein AM
Item number: Cay14948-1
Calcein AM is a cell-permeable dye that, upon entering live cells, is cleaved by intracellular esterases, leaving membrane-impermeant calcein (Cay-16221), a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively. It can be used as an indicator of cell viability, cell-cell...
| Keywords: | Calcein Acetoxymethyl ester, NSC 689290,... |
| Application: | Cell-permeable dye, cell viability assays |
| CAS | 148504-34-1 |
| MW: | 994.9 D |
From 120.00€
*
U-46619
Item number: Cay16450-1
U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist. It exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0,...
| Keywords: | 9,11-dideoxy-9alpha,11alpha-methanoepoxy PGF2alpha, 9,11-dideoxy-9alpha,11alpha-methanoepoxy Prostaglandin F2alpha,... |
| Application: | TP receptor agonist |
| CAS | 56985-40-1 |
| MW: | 350.5 D |
From 153.00€
*
Thapsigargin
Item number: Cay10522-1
Thapsigargin is an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = ~30 nM for the rat liver microsomal enzyme), an ER stress inducer, and a sesquiterpene lactone that has been found in Thapsia. It increases intracellular calcium levels in isolated rat hepatocytes (EC50 = ~80 nM) and...
| Keywords: | (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a... |
| Application: | SERCA inhibitor |
| CAS | 67526-95-8 |
| MW: | 650.8 D |
From 93.00€
*
Lipid-based Drug Delivery Tools
1,2-Dimyristoyl-sn-glycero-3-PE
Item number: Cay15090-250
Phosphatidylethanolamines (PEs) are phospholipids found in biological membranes, serving both structural and functional roles. Different types of PEs are commonly used in the generation of micelles, liposomes, and other types of artificial membranes. 1,2-Dimyristoyl-sn-glycero-3-PE (1,2-DMPE) is a phospholipid...
| Keywords: | 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, DMPE, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine |
| Application: | Phospholipid |
| CAS | 998-07-2 |
| MW: | 635.9 D |
From 78.00€
*
Bluo-Gal, pure
Item number: 50375.1
5-Bromo-3-Indolyl-ß-D-Galactopyranoside (Bluo-Gal) is a substrate for the histochemical localization of ß-galactosidase. Bluo-Gal is an alternative to X-Gal, producing a darker blue color.
| Keywords: | 5-Bromo-3-indolyl beta-D-galactopyranoside |
| Application: | beta-Galactosidase substrate |
| CAS | 97753-82-7 |
| MW: | 374.20 |
295.00€
*
Bicine, ultra pure
Item number: 01848.500
Bicine is an organic buffering agent. It is one of Good's buffers and has a pKa of 8.35 at 20°C. It is prepared by the reaction of glycine with ethylene oxide, followed by hydrolysis of the resultant lactone. Useful pH range: 7.8-8.8
| CAS | 150-25-4 |
| MW: | 163.17 |
From 138.00€
*