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PD 0325901
Item number: Cay13034-25
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation...
| Keywords: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Application: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482.2 D |
From 76.00€
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MG-132
Item number: AG-CP3-0011-M005
Soluble in DMSO or ethanol. Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kappaB activation inhibitor through IkappaB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin...
| Keywords: | Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, MG132 |
| Application: | Proteasome inhibitor |
| CAS | 133407-82-6 |
| MW: | 476 D |
From 22.00€
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2-deoxy-D-Glucose
Item number: Cay14325-1
2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis. It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate. 2-deoxy-D-glucose (16 mM) induces apoptosis in...
| Keywords: | Ba 2758, NSC 15193, 2-deoxy-D-arabino-hexose |
| Application: | Non-metabolizable glucose analog |
| CAS | 154-17-6 |
| MW: | 164.2 D |
From 82.00€
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5(S)-HETE-d8
Item number: Cay334230-25
5(S)-HETE-d8 is intended for use as an internal standard for the quantification of 5-HETE by GC- or LC-MS. (±)5-HETE is formed via non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 5(S)- and 5(R)-HETE are formed by lipoxygenase-mediated oxidation of arachidonic acid.Formal Name:...
| Keywords: | 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| Application: | Standard |
| CAS | 330796-62-8 |
| MW: | 328.5 D |
From 305.00€
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Cal-590(TM) potassium salt
Item number: ABD-20518
Ex: 573 nm. Em: 588 nm. Soluble in: water. Cal-590(TM) has been developed to improve Rhod-2 cell loading and calcium response while maintaining the spectral wavelength of Rhod-2, making it compatible with TRITC/Cy3(R) filter set. In CHO and HEK cells Cal-590(TM) AM has cellular calcium response that is much more...
| MW: | 1123.03 D |
291.00€
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3-Deazaneplanocin A
Item number: Cay13828-1
3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells...
| Keywords: | DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
| Application: | S-adenosyl-L-homosysteine hydrolase inhibitor |
| CAS | 102052-95-9 |
| MW: | 262.3 D |
From 149.00€
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Erlotinib
Item number: Cay10483-250
Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...
| Keywords: | NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| Application: | Tyrosine kinase inhibitor |
| CAS | 183321-74-6 |
| MW: | 393.4 D |
From 51.00€
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(2S)-Octyl-alpha-hydroxyglutarate
Item number: Cay16367-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Keywords: | (2S)-Octyl-2-HG, 2S-hydroxy-pentanedioic acid, 1-octyl ester |
| CAS | 1391194-64-1 |
| MW: | 260.3 D |
From 85.00€
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FDG (Fluorescein di-beta-D-galactopyranoside)
Item number: ABD-14001
Several orders of magnitude more sensitive than X-gal. FDG is considered to be one of the most sensitive fluorogenic substrates available for detecting beta-galactosidase.
| Application: | beta-galactosidase substrate |
| CAS | 17817-20-8 |
218.00€
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L-Ascorbic Acid 2-phosphate (magnesium salt hydrate)
Item number: Cay16457-5
L-Ascorbic acid (vitamin C, Cay-14656) is essential for the synthesis of collagen, with deficiency resulting in scurvy. Notably, humans and other primates, guinea pigs, and certain other animals lack an enzyme necessary for vitamin C synthesis. L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid...
| Keywords: | AA2P, Ascorbyl PM, L-Ascorbic Acid 2-phosphate (magnesium salt), Phospitan C, 2-(dihydrogen phosphate)-L-ascorbic acid,... |
| Application: | Long-acting ascorbic acid derivative, collagen expression stimulator |
| CAS | 1713265-25-8 |
| MW: | 292.6 D |
From 116.00€
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Tafluprost
Item number: Cay10005440-25
Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Cay-10005439) and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v. Ocular administration of tafluprost (0.0005% v/v)...
| Keywords: | AFP-168, 15,15-difluoro-9alpha,11alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl... |
| Application: | FP receptor agonist |
| CAS | 209860-87-7 |
| MW: | 452.5 D |
From 153.00€
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Staurosporine
Item number: Cay81590-1
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a...
| Keywords: | Stsp,... |
| Application: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466.5 D |
From 55.00€
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