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Leukotriene D4
Item number: Cay20310-25
Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Cay-20210) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by gamma-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal...
| Keywords: | LTD4, 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 73836-78-9 |
| MW: | 496.7 D |
From 239.00€
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Fingolimod (hydrochloride)
Item number: Cay10006292-50
Fingolimod is an immune modulator, a prodrug form of the sphingosine-1-phosphate (S1P) receptor agonist FTY720 phosphate (Cay-10008639), and a derivative of myriocin (Cay-63150). It selectively inhibits calcium-dependent cytosolic phospholipase A2 (cPLA2) over calcium-independent PLA2 (iPLA2) and secretory PLA2...
| Keywords: | FTY720, 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride |
| Application: | Immune Modulator |
| CAS | 162359-56-0 |
| MW: | 343.9 D |
From 116.00€
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Thromboxane B2-d4
Item number: Cay319030-25
Thromboxane B2-d4 (TXB2-d4) is intended for use as an internal standard for the quantification of TXB2 (Cay-19030) by GC- or LC-MS. TXB2 is a non-enzymatically derived, stable, inactive metabolite of TXA2, which is highly unstable. Serum levels of TXB2 positively correlate with platelet COX-1 activation. Urinary...
| Keywords: | TXB2-d4, 9alpha,11,15S-trihydroxy-thromba-5Z,13E-dien-1-oic-3,3,4,4-d4 acid |
| Application: | Standard |
| CAS | 1346112-79-5 |
| MW: | 374.5 D |
From 280.00€
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Sanguinarine (chloride)
Item number: Cay16951-10
Sanguinarine is a benzylisoquinoline alkaloid isolated from plants belonging to the family Papaveraceae. It exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines. Sanguinarine suppresses NF-kappaB activation by...
| Keywords: | 13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, monochloride |
| Application: | Benzylisoquinoline alkaloid |
| CAS | 5578-73-4 |
| MW: | 367.78 D |
From 51.00€
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EGTA AM
Item number: ABD-21005
EGTA AM is cell-permeable version of EGTA, a cell-permeable calcium chelator.
| Application: | Calcium chelator |
| CAS | 99590-86-0 |
218.00€
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Leukotriene C4
Item number: Cay20210-25
Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A)...
| Keywords: | LTC4, 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 72025-60-6 |
| MW: | 625.8 D |
From 239.00€
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Wortmannin
Item number: Cay10010591-1
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from...
| Keywords: | KY 12420,... |
| Application: | PI3K inhibitor |
| CAS | 19545-26-7 |
| MW: | 428.4 D |
From 74.00€
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(Suc-LLVY)2R110
Item number: ABD-13451
(Suc-LLVY)2R110 is a sentive fluorogenic substrate for 20S proteasome, calpains and other chymotrypsin-like proteases. The non-fluorescent substrate generates a bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set.
| Application: | Proteasome substrate |
145.00€
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Kifunensine
Item number: Cay10009437-1
Kifunensine was originally isolated from the actinomycete Kitasatosporia kifunensine No. 9482 and shown to be a weak inhibitor of aryl mannosidase. It has since been shown to be a potent and selective inhibitor of class I alpha-mannosidases and may serve as a key inhibitor of glycoprotein biosynthesis. Kifunensine...
| Keywords: | FR900494, hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione |
| Application: | Alpha-mannosidase inhibitor |
| CAS | 109944-15-2 |
| MW: | 232.2 D |
From 104.00€
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alpha-Hydroxymidazolam
Item number: Cay10385-5
alpha-Hydroxymidazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.Formal Name: 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol. CAS Number: 59468-90-5. Synonyms:...
| Keywords: | Ro 21-6347, alpha-Hydroxymidazolam, 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol |
| CAS | 59468-90-5 |
| MW: | 341.8 D |
From 223.00€
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6-keto Prostaglandin F1alpha
Item number: Cay15210-1
6-keto Prostaglandin F1alpha (6-keto PGF1alpha) is the inactive, non-enzymatic hydrolysis product of PGI2. 6-keto PGF1alpha serves as a useful marker of PGI2 biosynthesis in vivo. When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1alpha.Formal...
| Keywords: | 6-keto PGF1alpha, 6-oxo-9alpha,11alpha,15S-trihydroxy-prost-13E-en-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 58962-34-8 |
| MW: | 370.5 D |
From 149.00€
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13,14-dihydro-15-keto Prostaglandin D2
Item number: Cay12610-1
13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 (Cay-12010) which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor. It also inhibits ion flux in a canine colonic mucosa...
| Keywords: | 13,14-dihydro-15-keto PGD2, 9alpha-hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid |
| Application: | CRTH2 receptor agonist, DP2 receptor agonist |
| CAS | 59894-07-4 |
| MW: | 352.5 D |
From 199.00€
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