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Monensin (sodium salt)
Item number: Cay16488-1
Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus,...
| Keywords: | Monensin A, NSC 343257,... |
| Application: | Ionophorous antibiotic |
| CAS | 22373-78-0 |
| MW: | 692.9 D |
From 51.00€
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Oligomycin A
Item number: Cay11342-5
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis...
| Keywords: | MCH 32,... |
| Application: | Apoptosis inducer |
| CAS | 579-13-5 |
| MW: | 791.1 D |
From 87.00€
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Maresin 1
Item number: Cay10878-10
Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from docosahexaenoic acid (DHA, Cay-90310, Cay-17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-alpha-induced increases in reactive oxygen species (ROS) in...
| Keywords: | 7(R)-MaR1, 7(R)-Maresin 1, 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid |
| Application: | Inflammation studies |
| CAS | 1268720-28-0 |
| MW: | 360.5 D |
From 122.00€
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PSB-603
Item number: Cay25637-1
PSB-603 is an antagonist of the adenosine A2B receptor (Ki = 0.553 nM). It is selective for adenosine A2B over A1, A2A, and A3 receptors (Kis = >10,000 nM). It reduces intracellular calcium concentrations in Jurkat T cells expressing the human A2B receptor (IC50 = 1.13 nM). PSB-603 reduces Zika viral plaque...
| Keywords: | 8-[4-[[4-(4-chlorophenyl)-1-piperazinyl]sulfonyl]phenyl]-3,9-dihydro-1-propyl-1H-purine-2,6-dione |
| Application: | Adenosine receptor A2b antagonist |
| CAS | 1092351-10-4 |
| MW: | 529 D |
From 59.00€
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Indo-1, AM *Custom packaging*
Item number: ABD-21036
Indo-1 is the preferred dye for flow cytometry. Indo-1 AM is cell-permeable version of Indo-1.
| Application: | Cell-permeant fluorescent calcium indicator acetoxy-methyl ester, FC |
| CAS | 112926-02-0 |
From 218.00€
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Palmitic Acid
Item number: Cay10006627-10
Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively. Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid...
| Keywords: | C16:0, hexadecanoic acid |
| Application: | Bioactive lipid assays |
| CAS | 57-10-3 |
| MW: | 256.4 D |
From 62.00€
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Torin 1
Item number: Cay10997-10
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kalpha and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg...
| Keywords: | 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Application: | mTor inhibitor |
| CAS | 1222998-36-8 |
| MW: | 607.6 D |
From 224.00€
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(±)19(20)-EpDPA
Item number: Cay10175-500
(±)-19(20)-EpDPA is an epoxide metabolite of docosahexaenoic acid (DHA, Cay-90310, Cay-17950). It is formed from DHA by various cytochrome P450 (CYP) isoforms. In vivo, (±)-19(20)-EpDPA (100 ng/animal, i.p.) suppresses hepatic crown-like structure (hCLS) formation and liver fibrosis in wild-type, but not...
| Keywords: | (±)19,20 EDP, (±)19,20-EpDPE, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA,... |
| Application: | CYP450 metabolism studies |
| MW: | 344.5 D |
From 70.00€
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12-oxo Phytodienoic Acid
Item number: Cay88520-1
12-oxo Phytodienoic acid (OPDA) is a biologically active, immediate precursor of 7-epi jasmonic acid. In addition to its link with jasmonic acid activity, OPDA appears to play an independent role in mediating resistance to pathogens and pests. As an endogenous signal transducer, OPDA has been shown to increase...
| Keywords: | 12-oxo PDA, OPDA, 4-oxo-5alpha-2Z-pentenyl)-2-cyclopentene-1alpha-octanoic acid |
| Application: | Bioactive lipid assays |
| CAS | 85551-10-6 |
| MW: | 292.4 D |
From 132.00€
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Nitroblue Tetrazolium Chloride (NBT)
Item number: 06428.1
and other oxygenases. Often used in conjunction with BCIP (02291) for AP staining.
| Application: | Substrate for dehydrogenases |
| CAS | 298-83-9 |
| MW: | 817.64 |
From 158.00€
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G-418 (sulfate)
Item number: Cay13200-5
G-418 is an aminoglycoside antibiotic. It is active against T. thermophila (IC50 = 10 µM). It inhibits the 80S ribosome and protein elongation during translation in a cell-free assay when used at a concentration of 2 nM. G-418 is used in molecular biology as a selective agent in cell lines or plasmids containing the...
| Keywords: | Geneticin,... |
| Application: | Antibiotic |
| CAS | 108321-42-2 |
| MW: | 692.7 D |
From 87.00€
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Fluo-4 AM *Ultrapure Grade*
Item number: ABD-20551
Fluo-4 is an analog of Fluo-3 with the two chlorine substituents replaced by fluorines, which results in increased fluorescence excitation at 488 nm and consequently higher fluorescence signal levels. Cells may be loaded with the AM ester forms of these calcium indicators by adding the dissolved indicator directly...
| Application: | Fluorescent Ca2+ probe |
| CAS | 273221-67-3 |
| MW: | 1096.95 D |
From 145.00€
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