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Werner Syndrome RecQ Helicase-IN-2
Item number: Cay41678-1
An inhibitor of WRN (IC50 = 100 nM), selectively inhibits the growth of SW48 cells over DLD-1-WRN-KO cells (GI50s = 100 and >10,000 nM, respectively), reduces tumor volume in an SW48 mouse xenograft model at 120 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Werner Syndrome RecQ Helicase Inhibitor 2, WS RecQ Helicase Inhibitor 2, WS RecQ Helicase-IN-2,... |
| Application: | WRN inhibitor |
| CAS | 2869954-51-6 |
| MW: | 681.7 D |
From 153.00€
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Lipid A
Item number: Cay41708-1
An ionizable cationic lipid (pKa = 4.67). Formulation: A solution in ethanol. InChI: InChI=1S/C48H95NO5/c1-6-11-15-19-21-29-37-44(35-27-17-13-8-3)47(51)53-41-33-25-23-31-39-49(46(10-5)43-50)40-32-24-26-34-42-54-48(52)45(36-28-18-14-9-4)38-30-22-20-16-12-7-2/h44-46,50H,6-43H2,1-5H3. InChIKey:...
| Keywords: | 2-hexyl-decanoic acid, 1,1'-[[[1-(hydroxymethyl)propyl]imino]di-6,1-hexanediyl] ester |
| Application: | Ionizable cationic lipid |
| CAS | 2036273-20-6 |
| MW: | 766.27 D |
From 120.00€
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DC-U4106
Item number: Cay41723-1
A USP8 inhibitor (IC50 = 1.2 µM), selective for USP8 over USP2 and USP7 (IC50s = 58.4 and >100 µM, respectively), induces apoptosis in, and inhibits colony formation by, MCF-7 cells from 1-5 µM, reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg. Formulation: A solid. InChI:...
| Keywords: | 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-4H-1-benzopyran-4-one |
| Application: | USP8 inhibitor |
| CAS | 2410534-62-0 |
| MW: | 525.6 D |
From 223.00€
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Spongosine
Item number: Cay41832-1
A nucleoside with diverse biological activities, antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors), inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM, decreases...
| Keywords: | 2-Methoxyadenosine, NSC 36899, 2-methoxy-adenosine |
| Application: | Bioactive nucleoside |
| CAS | 24723-77-1 |
| MW: | 297.3 D |
From 76.00€
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MMV390048
Item number: Cay41835-10
A P. vivax PI4K inhibitor (IC50 = 3.4 nM), active against P. falciparum (IC50 = 28 nM), decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg), reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys at 20...
| Keywords: | 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
| Application: | Plasmodium vivax PI4K inhibitor |
| CAS | 1314883-11-8 |
| MW: | 393.4 D |
From 107.00€
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AQW-051
Item number: Cay41851-10
A partial agonist of the alpha7 nAChR, induces calcium influx in GH3 cells expressing alpha7 nAChR (EC50 = 38.9 nM), improves learning and memory in the social recognition test in mice at 0.03 or 0.3 mg/kg, improves learning and memory in the Morris water maze test in rats at 3 mg/kg, increases the duration of...
| Keywords: | VQW-765, (3R)-3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-1-azabicyclo[2.2.2]octane |
| Application: | alpha7 nAChR partial agonist |
| CAS | 669770-29-0 |
| MW: | 294.4 D |
From 104.00€
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DBCO acid
Item number: Cay41894-1
A copper-free click chemistry reagent, has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro, has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to...
| Keywords: | Dibenzocyclooctyne Acid, 11,12-didehydro-?-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid |
| Application: | Copper-free click chemistry reagent |
| CAS | 1353016-70-2 |
| MW: | 305.33 D |
From 43.00€
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4-Amino-D-phenylalanine
Item number: Cay41971-1
A synthetic amino acid and building block, has been used in the synthesis of CXCR4 antagonists. Formulation: A solid. InChI: InChI=1S/C9H12N2O2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,10-11H2,(H,12,13)/t8-/m1/s1. InChIKey: CMUHFUGDYMFHEI-MRVPVSSYSA-N. SMILES: OC([C@H](N)CC1=CC=C(C=C1)N)=O
| Keywords: | 4-NH2-D-Phe, p-Amino-D-phenylalanine, para-Amino-D-phenylalanine, (R)-2-amino-3-(4-aminophenyl)propanoic acid |
| Application: | Synthetic amino acid, building block |
| CAS | 102281-45-8 |
| MW: | 180.2 D |
From 132.00€
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EM-12-FS
Item number: Cay41983-10
An NTAQ1 degrader, binds to CRBN (IC50 = 256 nM) and covalently labels His353, reduces the levels of NTAQ1 in MOLT-4 cells in a NEDDylation-dependent manner at 1 and 5 µM. Formulation: A solid. InChI:...
| Keywords: | 3-[6-[(fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione |
| Application: | NTAQ1 degrader |
| CAS | 2839138-44-0 |
| MW: | 342.3 D |
From 137.00€
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KDS-0071
Item number: Cay41996-10
An imidazole-containing compound. Formulation: A solid. InChI: InChI=1S/C22H23FN4O3S/c23-18-12-16(6-7-17(18)13-26-8-10-31(29,30)11-9-26)19-2-1-3-21-24-20(14-27(19)21)25-22(28)15-4-5-15/h1-3,6-7,12,14-15H,4-5,8-11,13H2,(H,25,28). InChIKey: QDYVZZJCRDVVQG-UHFFFAOYSA-N. SMILES:...
| Keywords: | N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-cyclopropanecarboxamide |
| Application: | Imidazole-containing compound, JAK1 inhibitor |
| CAS | 1973485-18-5 |
| MW: | 442.5 D |
From 60.00€
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WYneN
Item number: Cay42010-10
A chemoselective probe for protein sulfenylation, selective for sulfenylated proteins over DNTB and 4-DPS, binds to sulfenylated proteins in live cells and can then be conjugated to azide-containing fluorescent probes for detection. Formulation: A solid. InChI:...
| Keywords: | Wittig-alkyne N, [2-oxo-2-(2-propyn-1-ylamino)ethyl]triphenyl-phosphonium, monobromide |
| Application: | Chemoselective protein sulfenylation probe |
| CAS | 3052492-38-0 |
| MW: | 438.3 D |
From 153.00€
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8alpha,9alpha-epoxy Hexahydrocannabinol
Item number: Cay42021-1
An analytical reference standard categorized as a phytocannabinoid metabolite, a metabolite of Delta8-THC, intended for research and forensic applications. Formulation: A solution in acetonitrile. InChI:...
| Keywords: | 8alpha,9alpha-EEHC, 8alpha,9alpha-epoxy HHC,... |
| Application: | Analytical reference standard, phytocannabinoid metabolite |
| CAS | 80513-76-4 |
| MW: | 330.5 D |
From 95.00€
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