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GLPG1205
Item number: Cay33185-1
A GPR84 antagonist, inhibits DIM-induced GTPgammaS binding in cells overexpressing human GPR84 (IC50 = 54 nM), inhibits embelin-induced chemotaxis of isolated human neutrophils (IC50 = 11 nM), reduces body weight loss and rectal bleeding and improves stool consistency in a rat model of DSS-induced colitis....
| Keywords: | 9-(2-cyclopropylethynyl)-2-[(2S)-1,4-dioxan-2-ylmethoxy]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one |
| Application: | GPR84 antagonist |
| CAS | 1445847-37-9 |
| MW: | 378.4 D |
From 101.00€
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Deferitazole
Item number: Cay33329-1
An iron chelator, decreases the levels of iron in iron-citrate complexes at 50 µM, reduces the number of P. falciparum oocytes, an effect that can be prevented by the addition of ferric chloride, and the percent of flagellated P. falciparum male gametocytes in vitro at 25 µM, decreases the urine and fecal levels of...
| Keywords: | FBS0701, SPD-602, 4S,5-dihydro-2-[2-hydroxy-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid |
| Application: | Iron chelator |
| CAS | 945635-15-4 |
| MW: | 399.46 D |
From 122.00€
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EN4
Item number: Cay33473-10
A covalent inhibitor of c-Myc, inhibits c-Myc-induced increases in transcriptional activity in a reporter assay using HEK293T cells (EC50 = 12.5 µM), reduces the proliferation of 231MFP cells at 50 µM, decreases tumor volume in a 231MFP mouse xenograft model at 50 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-benzamide |
| Application: | Covalent c-Myc inhibitor |
| CAS | 1197824-15-9 |
| MW: | 416.47 D |
From 101.00€
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ADB-4en-PINACA N-(4,5-dihydroxypentyl) metabolite
Item number: Cay33834-1
An analytical reference standard categorized as a synthetic cannabinoid metabolite, a metabolite of ADB-4en-PINACA, intended for research and forensic applications. Formulation: A solution in acetonitrile. InChI:...
| Keywords: | ADB-4en-PINACA dihydrodiol metabolite,... |
| Application: | Analytical reference standard, synthetic cannabinoid metabolite |
| MW: | 376.45 D |
From 290.00€
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alpha-Hydroxyphenazolam
Item number: Cay38503-1
An analytical reference standard categorized as a benzodiazepine metabolite, a metabolite of phenazolam, intended for research and forensic applications. Formulation: A solid. InChI: InChI=1S/C17H12BrClN4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2. InChIKey:...
| Keywords: | alpha-Hydroxyclobromazolam, (8-bromo-6-(2-chlorophenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)methanol |
| Application: | Analytical reference standard, benzodiazepine metabolite |
| MW: | 403.66 D |
From 180.00€
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6-methyl Etodesnitazene (citrate)
Item number: Cay39399-1
An analytical reference standard that is structurally similar to known opioids, intended for research and forensic applications. Formulation: A solid. InChI:...
| Keywords: | 6-methyl Desnitroetonitazene, 6-methyl Etazene, 6-methyl Etazone, Etomethazene,... |
| Application: | Analytical reference standard, structurally similar to known opioids |
| MW: | 557.64 D |
From 126.00€
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Delta4(8)-iso-THC (CRM)
Item number: Cay39955-100
A certified reference material that is structurally similar to known phytocannabinoids, an impurity in the conversion of cannabidiol to Delta8-THC or Delta9-THC, intended for research and forensic applications. Formulation: A 100 µg/ml solution in acetonitrile. InChI:...
| Keywords: | Delta4(8)-Isotetrahydrocannabinol,... |
| Application: | Certified reference material, structurally similar to known phytocannabinoids |
| MW: | 314.46 D |
189.00€
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Erinacine B
Item number: Cay40078-250
A cyathin diterpenoid, induces NGF secretion in isolated mouse astroglial cells at 1 mM. Formulation: A solution in acetonitrile. InChI:...
| Keywords: | (-)-Erinacine B, Erinacin B,... |
| Application: | Cyathin diterpenoid, fungal metabolite |
| CAS | 156101-10-9 |
| MW: | 432.6 D |
535.00€
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Perfluorohexyloctane
Item number: Cay40490-1
A semifluorinated alkane and PFAS, improves corneal penetration of cyclosporine A in porcine eyes ex vivo at 0.05 and 0.1%, topical application improves the lipid layer grade in rabbit eyes in vivo without inducing irritation. Formulation: A solid. InChI:...
| Keywords: | 1-(Perfluorohexyl)octane, F6H8, NOV03, 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-tetradecane |
| Application: | Semifluorinated alkane, PFAS |
| CAS | 133331-77-8 |
| MW: | 432.26 D |
376.00€
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BSJ-04-132
Item number: Cay41248-1
A PROTAC that drives Cdk4 degradation, selectively induces the degradation of Cdk4 over Cdk6, IKZF1, and IKZF3 in a cereblon-dependent manner in Jurkat cells at 1 µM. Formulation: A solid. InChI:...
| Keywords: | 7-cyclopentyl-2-[[5-[4-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]... |
| Application: | Cdk4 degradation driving PROTAC |
| CAS | 2349356392 |
| MW: | 819.9 D |
From 178.00€
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DMT7
Item number: Cay41389-1
An ionizable cationic lipid (pKa = 6.5), has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo, LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast...
| Keywords: | 1-(2-(dimethylamino)ethyl)-3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl)thiourea |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 658.2 D |
From 105.00€
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E17241
Item number: Cay41675-1
An inducer of ABCA1 expression, induces the expression of ABCA1 in a reporter assay using HepG2 cells (EC50 = 280 nM), an agonist of PPARs, induces PPAR-mediated gene expression in reporter assays using HepG2 cells expressing PPARgamma, PPARalpha, or PPARdelta (EC50s = 290, 3,900, and 879 nM, respectively),...
| Keywords: | 4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide, 4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide |
| Application: | ABCA1 expression inducer |
| CAS | 1060968-92-4 |
| MW: | 318.4 D |
From 70.00€
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